TY  - JOUR
AU  - Dam, Veerle
AU  - Onland-Moret, N Charlotte
AU  - Burgess, Stephen
AU  - Chirlaque, Maria-Dolores
AU  - Peters, Sanne A E
AU  - Schuit, Ewoud
AU  - Tikk, Kaja
AU  - Weiderpass, Elisabete
AU  - Oliver-Williams, Clare
AU  - Wood, Angela M
AU  - Tjønneland, Anne
AU  - Dahm, Christina C
AU  - Overvad, Kim
AU  - Boutron-Ruault, Marie-Christine
AU  - Schulze, Matthias B
AU  - Trichopoulou, Antonia
AU  - Ferrari, Pietro
AU  - Masala, Giovanna
AU  - Krogh, Vittorio
AU  - Tumino, Rosario
AU  - Matullo, Giuseppe
AU  - Panico, Salvatore
AU  - Boer, Jolanda M A
AU  - Verschuren, W M Monique
AU  - Waaseth, Marit
AU  - Sánchez Pérez, Maria José
AU  - Amiano, Pilar
AU  - Imaz, Liher
AU  - Moreno-Iribas, Conchi
AU  - Melander, Olle
AU  - Harlid, Sophia
AU  - Nordendahl, Maria
AU  - Wennberg, Patrik
AU  - Key, Timothy J
AU  - Riboli, Elio
AU  - Santiuste, Carmen
AU  - Kaaks, Rudolf
AU  - Katzke, Verena
AU  - Langenberg, Claudia
AU  - Wareham, Nicholas J
AU  - Schunkert, Heribert
AU  - Erdmann, Jeanette
AU  - Willenborg, Christina
AU  - Hengstenberg, Christian
AU  - Kleber, Marcus E
AU  - Delgado, Graciela
AU  - März, Winfried
AU  - Kanoni, Stavroula
AU  - Dedoussis, George
AU  - Deloukas, Panos
AU  - Nikpay, Majid
AU  - McPherson, Ruth
AU  - Scholz, Markus
AU  - Teren, Andrej
AU  - Butterworth, Adam S
AU  - van der Schouw, Yvonne T
TI  - Genetically determined reproductive aging and coronary heart disease: a bidirectional two-sample Mendelian Randomization.
JO  - The journal of clinical endocrinology & metabolism
VL  - 107
IS  - 7
SN  - 0021-972X
CY  - Oxford
PB  - Oxford University Press
M1  - DKFZ-2022-00512
SP  - e2952-e2961
PY  - 2022
N1  - 2022 Jun 16;107(7):e2952-e2961
AB  - Accelerated reproductive aging, in women indicated by early natural menopause, is associated with increased coronary heart disease (CHD) risk in observational studies. Conversely, an adverse CHD risk profile has been suggested to accelerate menopause.To study the direction and evidence for causality of the relationship between reproductive aging and (non-)fatal CHD and CHD risk factors in a bidirectional Mendelian Randomization (MR) approach, using age at natural menopause (ANM) genetic variants as a measure for genetically determined reproductive aging in women. We also studied the association of these variants with CHD risk (factors) in men.Two-sample MR, using both cohort data as well as summary statistics, with four methods: simple and weighted median-based, standard inverse-variance weighted (IVW) regression, and MR-Egger regression.Data from EPIC-CVD and summary statistics from UK Biobank and publicly available GWAS were pooled for the different analyses.CHD, CHD risk factors and ANM.Across different methods of MR no association was found between genetically determined reproductive aging and CHD risk in women (Relative Risk Estimate (RRE)IVW=0.99, 95
KW  - Mendelian Randomization (Other)
KW  - Reproductive aging (Other)
KW  - coronary heart disease (Other)
KW  - risk factors (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:35306566
DO  - DOI:10.1210/clinem/dgac171
UR  - https://inrepo02.dkfz.de/record/179162
ER  -