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@ARTICLE{Dam:179162,
      author       = {V. Dam and N. C. Onland-Moret and S. Burgess and M.-D.
                      Chirlaque and S. A. E. Peters and E. Schuit and K. Tikk$^*$
                      and E. Weiderpass and C. Oliver-Williams and A. M. Wood and
                      A. Tjønneland and C. C. Dahm and K. Overvad and M.-C.
                      Boutron-Ruault and M. B. Schulze and A. Trichopoulou and P.
                      Ferrari and G. Masala and V. Krogh and R. Tumino and G.
                      Matullo and S. Panico and J. M. A. Boer and W. M. M.
                      Verschuren and M. Waaseth and M. J. Sánchez Pérez and P.
                      Amiano and L. Imaz and C. Moreno-Iribas and O. Melander and
                      S. Harlid and M. Nordendahl and P. Wennberg and T. J. Key
                      and E. Riboli and C. Santiuste and R. Kaaks$^*$ and V.
                      Katzke$^*$ and C. Langenberg and N. J. Wareham and H.
                      Schunkert and J. Erdmann and C. Willenborg and C.
                      Hengstenberg and M. E. Kleber and G. Delgado and W. März
                      and S. Kanoni and G. Dedoussis and P. Deloukas and M. Nikpay
                      and R. McPherson and M. Scholz and A. Teren and A. S.
                      Butterworth and Y. T. van der Schouw},
      title        = {{G}enetically determined reproductive aging and coronary
                      heart disease: a bidirectional two-sample {M}endelian
                      {R}andomization.},
      journal      = {The journal of clinical endocrinology $\&$ metabolism},
      volume       = {107},
      number       = {7},
      issn         = {0021-972X},
      address      = {Oxford},
      publisher    = {Oxford University Press},
      reportid     = {DKFZ-2022-00512},
      pages        = {e2952-e2961},
      year         = {2022},
      note         = {2022 Jun 16;107(7):e2952-e2961},
      abstract     = {Accelerated reproductive aging, in women indicated by early
                      natural menopause, is associated with increased coronary
                      heart disease (CHD) risk in observational studies.
                      Conversely, an adverse CHD risk profile has been suggested
                      to accelerate menopause.To study the direction and evidence
                      for causality of the relationship between reproductive aging
                      and (non-)fatal CHD and CHD risk factors in a bidirectional
                      Mendelian Randomization (MR) approach, using age at natural
                      menopause (ANM) genetic variants as a measure for
                      genetically determined reproductive aging in women. We also
                      studied the association of these variants with CHD risk
                      (factors) in men.Two-sample MR, using both cohort data as
                      well as summary statistics, with four methods: simple and
                      weighted median-based, standard inverse-variance weighted
                      (IVW) regression, and MR-Egger regression.Data from EPIC-CVD
                      and summary statistics from UK Biobank and publicly
                      available GWAS were pooled for the different analyses.CHD,
                      CHD risk factors and ANM.Across different methods of MR no
                      association was found between genetically determined
                      reproductive aging and CHD risk in women (Relative Risk
                      Estimate (RRE)IVW=0.99, $95\%$ confidence interval
                      (CI):0.97;1.01), or any of the CHD risk factors. Similarly,
                      no associations were found in men. Neither did the reversed
                      analyses show evidence for an association between CHD (risk
                      factors) and reproductive aging.Genetically determined
                      reproductive aging is not causally associated with CHD risk
                      (factors) in women, nor were the genetic variants associated
                      in men. We found no evidence for a reverse association in a
                      combined sample of women and men.},
      keywords     = {Mendelian Randomization (Other) / Reproductive aging
                      (Other) / coronary heart disease (Other) / risk factors
                      (Other)},
      cin          = {C070 / HD01 / C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331 / I:(DE-He78)HD01-20160331 /
                      I:(DE-He78)C020-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:35306566},
      doi          = {10.1210/clinem/dgac171},
      url          = {https://inrepo02.dkfz.de/record/179162},
}