000179247 001__ 179247
000179247 005__ 20240229145537.0
000179247 0247_ $$2doi$$a10.1126/sciadv.abh4050
000179247 0247_ $$2pmid$$apmid:35319989
000179247 0247_ $$2altmetric$$aaltmetric:125197016
000179247 037__ $$aDKFZ-2022-00529
000179247 041__ $$aEnglish
000179247 082__ $$a500
000179247 1001_ $$0P:(DE-He78)51635089578f68fc9efdb61e6a760b64$$aWalle, Thomas$$b0$$eFirst author$$udkfz
000179247 245__ $$aRadiotherapy orchestrates natural killer cell dependent antitumor immune responses through CXCL8.
000179247 260__ $$aWashington, DC [u.a.]$$bAssoc.$$c2022
000179247 3367_ $$2DRIVER$$aarticle
000179247 3367_ $$2DataCite$$aOutput Types/Journal article
000179247 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1648641779_12909
000179247 3367_ $$2BibTeX$$aARTICLE
000179247 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000179247 3367_ $$00$$2EndNote$$aJournal Article
000179247 500__ $$a#EA:E055#LA:E055#
000179247 520__ $$aRadiotherapy is a mainstay cancer therapy whose antitumor effects partially depend on T cell responses. However, the role of Natural Killer (NK) cells in radiotherapy remains unclear. Here, using a reverse translational approach, we show a central role of NK cells in the radiation-induced immune response involving a CXCL8/IL-8-dependent mechanism. In a randomized controlled pancreatic cancer trial, CXCL8 increased under radiotherapy, and NK cell positively correlated with prolonged overall survival. Accordingly, NK cells preferentially infiltrated irradiated pancreatic tumors and exhibited CD56dim-like cytotoxic transcriptomic states. In experimental models, NF-κB and mTOR orchestrated radiation-induced CXCL8 secretion from tumor cells with senescence features causing directional migration of CD56dim NK cells, thus linking senescence-associated CXCL8 release to innate immune surveillance of human tumors. Moreover, combined high-dose radiotherapy and adoptive NK cell transfer improved tumor control over monotherapies in xenografted mice, suggesting NK cells combined with radiotherapy as a rational cancer treatment strategy.
000179247 536__ $$0G:(DE-HGF)POF4-315$$a315 - Bildgebung und Radioonkologie (POF4-315)$$cPOF4-315$$fPOF IV$$x0
000179247 588__ $$aDataset connected to CrossRef, PubMed, , Journals: inrepo02.dkfz.de
000179247 7001_ $$0P:(DE-He78)7fb0841f5e88928308e29474e3170818$$aKraske, Joscha$$b1$$udkfz
000179247 7001_ $$0P:(DE-He78)c3341cb95b840ce8a9365b013a464e41$$aLiao, Boyu$$b2$$udkfz
000179247 7001_ $$0P:(DE-He78)4671d97058e8d2ddb314e6be4de0c403$$aLenoir, Bénédicte$$b3$$udkfz
000179247 7001_ $$00000-0003-0256-6625$$aTimke, Carmen$$b4
000179247 7001_ $$0P:(DE-He78)10877b4f46992f46a4fafc3e16e40eb3$$avon Bohlen Und Halbach, Emilia$$b5
000179247 7001_ $$00000-0002-3735-9872$$aTran, Florian$$b6
000179247 7001_ $$00000-0001-5671-8183$$aGriebel, Paul$$b7
000179247 7001_ $$0P:(DE-He78)6d885f5506bfb36244e75a3a016af7fa$$aAlbrecht, Dorothee$$b8$$udkfz
000179247 7001_ $$0P:(DE-He78)bac8c2c56238485ecf0475ff14438430$$aAhmed, Azaz$$b9$$udkfz
000179247 7001_ $$0P:(DE-He78)7eaaf5131f5096c7ff7de12dde4ceca5$$aSuarez-Carmona, Meggy$$b10$$udkfz
000179247 7001_ $$00000-0003-1879-7057$$aJiménez-Sánchez, Alejandro$$b11
000179247 7001_ $$0P:(DE-He78)53d20e6d4d85019eeb3f21bb93ae62fa$$aBeikert, Tizian$$b12$$udkfz
000179247 7001_ $$00000-0003-1489-3885$$aTietz-Dahlfuß, Alexandra$$b13
000179247 7001_ $$aMenevse, Ayse Nur$$b14
000179247 7001_ $$0P:(DE-He78)e8868a5fc184fe2e756d7e11ad1ac748$$aSchmidt, Gabriele$$b15$$udkfz
000179247 7001_ $$0P:(DE-He78)2e781085118732ec90737b79c643a9d1$$aBrom, Manuela$$b16$$udkfz
000179247 7001_ $$aPahl, Jens H W$$b17
000179247 7001_ $$aAntonopoulos, Wiebke$$b18
000179247 7001_ $$aMiller, Matthias$$b19
000179247 7001_ $$00000-0002-6876-2074$$aPerez, Ramon Lopez$$b20
000179247 7001_ $$0P:(DE-He78)89e155931400aa7bb80b79b6be41f979$$aBestvater, Felix$$b21$$udkfz
000179247 7001_ $$aGiese, Nathalia A$$b22
000179247 7001_ $$aBeckhove, Philipp$$b23
000179247 7001_ $$00000-0002-9692-8828$$aRosenstiel, Philip$$b24
000179247 7001_ $$0P:(DE-He78)ed0321409c9cde20b380ae663dbcefd1$$aJäger, Dirk$$b25$$udkfz
000179247 7001_ $$aStrobel, Oliver$$b26
000179247 7001_ $$00000-0002-9259-8817$$aPe'er, Dana$$b27
000179247 7001_ $$0P:(DE-He78)0a4053be7ffd6aa9bef69de28753a601$$aHalama, Niels$$b28$$udkfz
000179247 7001_ $$aDebus, Jürgen$$b29
000179247 7001_ $$aCerwenka, Adelheid$$b30
000179247 7001_ $$0P:(DE-He78)3291aaac20f3d603d96744c1f0890028$$aHuber, Peter$$b31$$eLast author$$udkfz
000179247 773__ $$0PERI:(DE-600)2810933-8$$a10.1126/sciadv.abh4050$$gVol. 8, no. 12, p. eabh4050$$n12$$peabh4050$$tScience advances$$v8$$x2375-2548$$y2022
000179247 909CO $$ooai:inrepo02.dkfz.de:179247$$pVDB
000179247 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)51635089578f68fc9efdb61e6a760b64$$aDeutsches Krebsforschungszentrum$$b0$$kDKFZ
000179247 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)7fb0841f5e88928308e29474e3170818$$aDeutsches Krebsforschungszentrum$$b1$$kDKFZ
000179247 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)c3341cb95b840ce8a9365b013a464e41$$aDeutsches Krebsforschungszentrum$$b2$$kDKFZ
000179247 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)4671d97058e8d2ddb314e6be4de0c403$$aDeutsches Krebsforschungszentrum$$b3$$kDKFZ
000179247 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)10877b4f46992f46a4fafc3e16e40eb3$$aDeutsches Krebsforschungszentrum$$b5$$kDKFZ
000179247 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)6d885f5506bfb36244e75a3a016af7fa$$aDeutsches Krebsforschungszentrum$$b8$$kDKFZ
000179247 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)bac8c2c56238485ecf0475ff14438430$$aDeutsches Krebsforschungszentrum$$b9$$kDKFZ
000179247 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)7eaaf5131f5096c7ff7de12dde4ceca5$$aDeutsches Krebsforschungszentrum$$b10$$kDKFZ
000179247 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)53d20e6d4d85019eeb3f21bb93ae62fa$$aDeutsches Krebsforschungszentrum$$b12$$kDKFZ
000179247 9101_ $$0I:(DE-588b)2036810-0$$60000-0003-1489-3885$$aDeutsches Krebsforschungszentrum$$b13$$kDKFZ
000179247 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)e8868a5fc184fe2e756d7e11ad1ac748$$aDeutsches Krebsforschungszentrum$$b15$$kDKFZ
000179247 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)2e781085118732ec90737b79c643a9d1$$aDeutsches Krebsforschungszentrum$$b16$$kDKFZ
000179247 9101_ $$0I:(DE-588b)2036810-0$$60000-0002-6876-2074$$aDeutsches Krebsforschungszentrum$$b20$$kDKFZ
000179247 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)89e155931400aa7bb80b79b6be41f979$$aDeutsches Krebsforschungszentrum$$b21$$kDKFZ
000179247 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)ed0321409c9cde20b380ae663dbcefd1$$aDeutsches Krebsforschungszentrum$$b25$$kDKFZ
000179247 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)0a4053be7ffd6aa9bef69de28753a601$$aDeutsches Krebsforschungszentrum$$b28$$kDKFZ
000179247 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)3291aaac20f3d603d96744c1f0890028$$aDeutsches Krebsforschungszentrum$$b31$$kDKFZ
000179247 9131_ $$0G:(DE-HGF)POF4-315$$1G:(DE-HGF)POF4-310$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lKrebsforschung$$vBildgebung und Radioonkologie$$x0
000179247 9141_ $$y2022
000179247 915__ $$0LIC:(DE-HGF)CCBYNCNV$$2V:(DE-HGF)$$aCreative Commons Attribution-NonCommercial CC BY-NC (No Version)$$bDOAJ$$d2021-01-30
000179247 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2021-01-30
000179247 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2021-01-30
000179247 915__ $$0StatID:(DE-HGF)0561$$2StatID$$aArticle Processing Charges$$d2021-01-30
000179247 915__ $$0StatID:(DE-HGF)0700$$2StatID$$aFees$$d2021-01-30
000179247 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bSCI ADV : 2021$$d2022-11-08
000179247 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2022-11-08
000179247 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2022-11-08
000179247 915__ $$0StatID:(DE-HGF)0501$$2StatID$$aDBCoverage$$bDOAJ Seal$$d2021-09-20T13:50:30Z
000179247 915__ $$0StatID:(DE-HGF)0500$$2StatID$$aDBCoverage$$bDOAJ$$d2021-09-20T13:50:30Z
000179247 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bDOAJ : Blind peer review$$d2021-09-20T13:50:30Z
000179247 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search$$d2022-11-08
000179247 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC$$d2022-11-08
000179247 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2022-11-08
000179247 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2022-11-08
000179247 915__ $$0StatID:(DE-HGF)1040$$2StatID$$aDBCoverage$$bZoological Record$$d2022-11-08
000179247 915__ $$0StatID:(DE-HGF)1150$$2StatID$$aDBCoverage$$bCurrent Contents - Physical, Chemical and Earth Sciences$$d2022-11-08
000179247 915__ $$0StatID:(DE-HGF)9910$$2StatID$$aIF >= 10$$bSCI ADV : 2021$$d2022-11-08
000179247 9202_ $$0I:(DE-He78)E055-20160331$$kE055$$lE055 KKE Translationale Radioonkologie$$x0
000179247 9200_ $$0I:(DE-He78)E055-20160331$$kE055$$lE055 KKE Translationale Radioonkologie$$x0
000179247 9201_ $$0I:(DE-He78)E055-20160331$$kE055$$lE055 KKE Translationale Radioonkologie$$x0
000179247 9201_ $$0I:(DE-He78)HD01-20160331$$kHD01$$lDKTK HD zentral$$x1
000179247 9201_ $$0I:(DE-He78)D120-20160331$$kD120$$lD120 Angewandte Tumor-Immunität$$x2
000179247 9201_ $$0I:(DE-He78)D240-20160331$$kD240$$lTranslationale Immuntherapie$$x3
000179247 9201_ $$0I:(DE-He78)W210-20160331$$kW210$$lLichtmikroskopie$$x4
000179247 980__ $$ajournal
000179247 980__ $$aVDB
000179247 980__ $$aI:(DE-He78)E055-20160331
000179247 980__ $$aI:(DE-He78)HD01-20160331
000179247 980__ $$aI:(DE-He78)D120-20160331
000179247 980__ $$aI:(DE-He78)D240-20160331
000179247 980__ $$aI:(DE-He78)W210-20160331
000179247 980__ $$aUNRESTRICTED