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@ARTICLE{Walle:179247,
      author       = {T. Walle$^*$ and J. Kraske$^*$ and B. Liao$^*$ and B.
                      Lenoir$^*$ and C. Timke and E. von Bohlen Und Halbach$^*$
                      and F. Tran and P. Griebel and D. Albrecht$^*$ and A.
                      Ahmed$^*$ and M. Suarez-Carmona$^*$ and A. Jiménez-Sánchez
                      and T. Beikert$^*$ and A. Tietz-Dahlfuß$^*$ and A. N.
                      Menevse and G. Schmidt$^*$ and M. Brom$^*$ and J. H. W. Pahl
                      and W. Antonopoulos and M. Miller and R. L. Perez$^*$ and F.
                      Bestvater$^*$ and N. A. Giese and P. Beckhove and P.
                      Rosenstiel and D. Jäger$^*$ and O. Strobel and D. Pe'er and
                      N. Halama$^*$ and J. Debus and A. Cerwenka and P. Huber$^*$},
      title        = {{R}adiotherapy orchestrates natural killer cell dependent
                      antitumor immune responses through {CXCL}8.},
      journal      = {Science advances},
      volume       = {8},
      number       = {12},
      issn         = {2375-2548},
      address      = {Washington, DC [u.a.]},
      publisher    = {Assoc.},
      reportid     = {DKFZ-2022-00529},
      pages        = {eabh4050},
      year         = {2022},
      note         = {#EA:E055#LA:E055#},
      abstract     = {Radiotherapy is a mainstay cancer therapy whose antitumor
                      effects partially depend on T cell responses. However, the
                      role of Natural Killer (NK) cells in radiotherapy remains
                      unclear. Here, using a reverse translational approach, we
                      show a central role of NK cells in the radiation-induced
                      immune response involving a CXCL8/IL-8-dependent mechanism.
                      In a randomized controlled pancreatic cancer trial, CXCL8
                      increased under radiotherapy, and NK cell positively
                      correlated with prolonged overall survival. Accordingly, NK
                      cells preferentially infiltrated irradiated pancreatic
                      tumors and exhibited CD56dim-like cytotoxic transcriptomic
                      states. In experimental models, NF-κB and mTOR orchestrated
                      radiation-induced CXCL8 secretion from tumor cells with
                      senescence features causing directional migration of CD56dim
                      NK cells, thus linking senescence-associated CXCL8 release
                      to innate immune surveillance of human tumors. Moreover,
                      combined high-dose radiotherapy and adoptive NK cell
                      transfer improved tumor control over monotherapies in
                      xenografted mice, suggesting NK cells combined with
                      radiotherapy as a rational cancer treatment strategy.},
      cin          = {E055 / HD01 / D120 / D240 / W210},
      ddc          = {500},
      cid          = {I:(DE-He78)E055-20160331 / I:(DE-He78)HD01-20160331 /
                      I:(DE-He78)D120-20160331 / I:(DE-He78)D240-20160331 /
                      I:(DE-He78)W210-20160331},
      pnm          = {315 - Bildgebung und Radioonkologie (POF4-315)},
      pid          = {G:(DE-HGF)POF4-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:35319989},
      doi          = {10.1126/sciadv.abh4050},
      url          = {https://inrepo02.dkfz.de/record/179247},
}