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@ARTICLE{VanderWeijst:179278,
      author       = {L. Van der Weijst and M. E. Aguado-Barrera and D. Azria and
                      P. Berkovic and P. Boisselier and E. Briers and R. Bultijnck
                      and P. Calvo-Crespo and J. Chang-Claude$^*$ and A. Choudhury
                      and G. Defraene and S. Demontois and A. M. Dunning and R. M.
                      Elliott and D. Ennis and C. Faivre-Finn and M. Franceschini
                      and S. Gutiérrez-Enríquez and C. Herskind and D. S.
                      Higginson and S. L. Kerns and K. Johnson and M. Mollà and
                      M. Lambrecht and M. Ramos and T. Rancati and A. Rimner and
                      B. S. Rosenstein and D. De Ruysscher and A. Salem and C.
                      Sangalli and P. Seibold$^*$ and P. Sosa-Fajardo and E. Sperk
                      and H. Stobart and H. Summersgill and V. Surmont and P.
                      Symonds and B. Taboada-Lorenzo and C. J. Talbot and R.
                      Valdagni and A. Vega and L. Veldeman and M. R. Veldwijk and
                      T. Ward and A. Webb and C. M. L. West and Y. Lievens},
      collaboration = {R. Consortium},
      title        = {{O}verview of health-related quality of life and toxicity
                      of non-small cell lung cancer patients receiving
                      curative-intent radiotherapy in a real-life setting (the
                      {REQUITE} study).},
      journal      = {Lung cancer},
      volume       = {166},
      issn         = {0169-5002},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier},
      reportid     = {DKFZ-2022-00560},
      pages        = {228 - 241},
      year         = {2022},
      abstract     = {Radiotherapy-induced toxicity may negatively impact
                      health-related quality of life (HRQoL). This report
                      investigates the impact of curative-intent radiotherapy on
                      HRQoL and toxicity in early stage and locally-advanced
                      non-small cell lung cancer patients treated with
                      radiotherapy or chemo-radiotherapy enrolled in the
                      observational prospective REQUITE study.HRQoL was assessed
                      using the European Organisation for Research and Treatment
                      of Cancer QLQ-C30 questionnaire up to 2 years post
                      radiotherapy. Eleven toxicities were scored by clinicians
                      using the Common Terminology Criteria for Adverse Events
                      (CTCAE) version 4. Toxicity scores were calculated by
                      subtracting baseline values. Mixed model analyses were
                      applied to determine statistical significance (p ≤ 0.01).
                      Meaningful clinical important differences (MCID) were
                      determined for changes in HRQoL. Analysis was performed on
                      the overall data, different radiotherapy techniques,
                      multimodality treatments and disease stages.Data of 510
                      patients were analysed. There was no significant change in
                      HRQoL or its domains, except for deterioration in cognitive
                      functioning (p = 0.01). Radiotherapy technique had no
                      significant impact on HRQoL. The addition of chemotherapy
                      was significantly associated with HRQoL over time (p <.001).
                      Overall toxicity did not significantly change over time.
                      Acute toxicities of radiation-dermatitis (p =.003),
                      dysphagia (p =.002) and esophagitis (p <.001) peaked at 3
                      months and decreased thereafter. Pneumonitis initially
                      deteriorated but improved significantly after 12 months (p
                      =.011). A proportion of patients experienced meaningful
                      clinically important improvements and deteriorations in
                      overall HRQoL and its domains. In some patients,
                      pre-treatment symptoms improved gradually.While overall
                      HRQoL and toxicity did not change over time, some patients
                      improved, whereas others experienced acute
                      radiotherapy-induced toxicities and deteriorated HRQoL,
                      especially physical and cognitive functioning. Patient
                      characteristics, more so than radiotherapy technique and
                      treatment modality, impact post-radiotherapy toxicity and
                      HRQoL outcomes. This stresses the importance of considering
                      the potential impact of radiotherapy on individuals' HRQoL,
                      symptoms and toxicity in treatment decision-making.},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:35334417},
      doi          = {10.1016/j.lungcan.2022.03.010},
      url          = {https://inrepo02.dkfz.de/record/179278},
}