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000179281 0247_ $$2doi$$a10.1016/j.cgh.2022.03.013
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000179281 041__ $$aEnglish
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000179281 1001_ $$0P:(DE-He78)0311ebf3415e41860b4e2c56fbae6919$$aGuo, Feng$$b0$$eFirst author
000179281 245__ $$aPolygenic risk score for defining personalized surveillance intervals after adenoma detection and removal at colonoscopy.
000179281 260__ $$aNew York, NY$$bElsevier Science$$c2023
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000179281 500__ $$a#EA:C070#LA:C070#LA:C120# / 2023 Jan;21(1):210-219.e11
000179281 520__ $$aPolygenic risk scores (PRSs) could help to define personalized colorectal cancer (CRC) screening strategies. The aim of this study was to evaluate whether a PRS, along with adenoma characteristics, could help to define more personalized and risk-adapted surveillance intervals.In a population-based case-control study from Germany, detailed information on previous colonoscopies and a PRS based on 140 CRC-related single-nucleotide polymorphisms was obtained from 4696 CRC cases and 3709 controls. Participants were classified as having low, medium, or high genetic risk according to tertiles of PRSs among controls. We calculated the absolute risk of CRC based on the PRS and colonoscopy history and findings.We observed major variation of CRC risk according to the PRS, including among individuals with detection and removal of adenomas at colonoscopy. For instance, the estimated 10-year absolute risk of CRC for 50-year-old men and women with no polyps, for whom repeat screening colonoscopy is recommended after 10 years only, was 0.2%. Equivalent absolute risks were estimated for people with low-risk adenomas and low PRS. However, the same levels of absolute risk were reached within 3-5 years by those with low-risk adenomas and high PRS and with high-risk adenomas irrespective of the PRS.Consideration of genetic predisposition to CRC risk, as determined by a PRS, could help to define personalized, risk-adapted surveillance intervals after detection and removal of adenomas at screening colonoscopy. However, whether the risk variation is strong enough to direct clinical risk stratification needs to be further explored.
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000179281 650_7 $$2Other$$aAdenoma
000179281 650_7 $$2Other$$aColonoscopy
000179281 650_7 $$2Other$$aColorectal cancer
000179281 650_7 $$2Other$$aGenetic risk
000179281 650_7 $$2Other$$aSurveillance
000179281 7001_ $$0P:(DE-He78)92820b4867c955a04f642707ecf35b40$$aEdelmann, Dominic$$b1
000179281 7001_ $$0P:(DE-HGF)0$$aCardoso, Rafael$$b2
000179281 7001_ $$0P:(DE-He78)c392ec8a090dcfbe801f135a6212caf9$$aChen, Xuechen$$b3
000179281 7001_ $$0P:(DE-He78)7d7ee36ed0313bbc4c91bc3df5950107$$aCarr, Prudence$$b4
000179281 7001_ $$0P:(DE-He78)c259d6cc99edf5c7bc7ce22c7f87c253$$aChang-Claude, Jenny$$b5
000179281 7001_ $$0P:(DE-He78)6c5d058b7552d071a7fa4c5e943fff0f$$aHoffmeister, Michael$$b6
000179281 7001_ $$0P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2$$aBrenner, Hermann$$b7$$eLast author
000179281 773__ $$0PERI:(DE-600)2102638-5$$a10.1016/j.cgh.2022.03.013$$gp. S1542356522002889$$n1$$p210-219.e11$$tClinical gastroenterology and hepatology$$v21$$x1542-3565$$y2023
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