TY  - JOUR
AU  - Guo, Feng
AU  - Edelmann, Dominic
AU  - Cardoso, Rafael
AU  - Chen, Xuechen
AU  - Carr, Prudence
AU  - Chang-Claude, Jenny
AU  - Hoffmeister, Michael
AU  - Brenner, Hermann
TI  - Polygenic risk score for defining personalized surveillance intervals after adenoma detection and removal at colonoscopy.
JO  - Clinical gastroenterology and hepatology
VL  - 21
IS  - 1
SN  - 1542-3565
CY  - New York, NY
PB  - Elsevier Science
M1  - DKFZ-2022-00563
SP  - 210-219.e11
PY  - 2023
N1  - #EA:C070#LA:C070#LA:C120# / 2023 Jan;21(1):210-219.e11
AB  - Polygenic risk scores (PRSs) could help to define personalized colorectal cancer (CRC) screening strategies. The aim of this study was to evaluate whether a PRS, along with adenoma characteristics, could help to define more personalized and risk-adapted surveillance intervals.In a population-based case-control study from Germany, detailed information on previous colonoscopies and a PRS based on 140 CRC-related single-nucleotide polymorphisms was obtained from 4696 CRC cases and 3709 controls. Participants were classified as having low, medium, or high genetic risk according to tertiles of PRSs among controls. We calculated the absolute risk of CRC based on the PRS and colonoscopy history and findings.We observed major variation of CRC risk according to the PRS, including among individuals with detection and removal of adenomas at colonoscopy. For instance, the estimated 10-year absolute risk of CRC for 50-year-old men and women with no polyps, for whom repeat screening colonoscopy is recommended after 10 years only, was 0.2
KW  - Adenoma (Other)
KW  - Colonoscopy (Other)
KW  - Colorectal cancer (Other)
KW  - Genetic risk (Other)
KW  - Surveillance (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:35331942
DO  - DOI:10.1016/j.cgh.2022.03.013
UR  - https://inrepo02.dkfz.de/record/179281
ER  -