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@ARTICLE{Guo:179281,
      author       = {F. Guo$^*$ and D. Edelmann$^*$ and R. Cardoso$^*$ and X.
                      Chen$^*$ and P. Carr$^*$ and J. Chang-Claude$^*$ and M.
                      Hoffmeister$^*$ and H. Brenner$^*$},
      title        = {{P}olygenic risk score for defining personalized
                      surveillance intervals after adenoma detection and removal
                      at colonoscopy.},
      journal      = {Clinical gastroenterology and hepatology},
      volume       = {21},
      number       = {1},
      issn         = {1542-3565},
      address      = {New York, NY},
      publisher    = {Elsevier Science},
      reportid     = {DKFZ-2022-00563},
      pages        = {210-219.e11},
      year         = {2023},
      note         = {#EA:C070#LA:C070#LA:C120# / 2023 Jan;21(1):210-219.e11},
      abstract     = {Polygenic risk scores (PRSs) could help to define
                      personalized colorectal cancer (CRC) screening strategies.
                      The aim of this study was to evaluate whether a PRS, along
                      with adenoma characteristics, could help to define more
                      personalized and risk-adapted surveillance intervals.In a
                      population-based case-control study from Germany, detailed
                      information on previous colonoscopies and a PRS based on 140
                      CRC-related single-nucleotide polymorphisms was obtained
                      from 4696 CRC cases and 3709 controls. Participants were
                      classified as having low, medium, or high genetic risk
                      according to tertiles of PRSs among controls. We calculated
                      the absolute risk of CRC based on the PRS and colonoscopy
                      history and findings.We observed major variation of CRC risk
                      according to the PRS, including among individuals with
                      detection and removal of adenomas at colonoscopy. For
                      instance, the estimated 10-year absolute risk of CRC for
                      50-year-old men and women with no polyps, for whom repeat
                      screening colonoscopy is recommended after 10 years only,
                      was $0.2\%.$ Equivalent absolute risks were estimated for
                      people with low-risk adenomas and low PRS. However, the same
                      levels of absolute risk were reached within 3-5 years by
                      those with low-risk adenomas and high PRS and with high-risk
                      adenomas irrespective of the PRS.Consideration of genetic
                      predisposition to CRC risk, as determined by a PRS, could
                      help to define personalized, risk-adapted surveillance
                      intervals after detection and removal of adenomas at
                      screening colonoscopy. However, whether the risk variation
                      is strong enough to direct clinical risk stratification
                      needs to be further explored.},
      keywords     = {Adenoma (Other) / Colonoscopy (Other) / Colorectal cancer
                      (Other) / Genetic risk (Other) / Surveillance (Other)},
      cin          = {C070 / C060 / C120 / C020 / HD01},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331 / I:(DE-He78)C060-20160331 /
                      I:(DE-He78)C120-20160331 / I:(DE-He78)C020-20160331 /
                      I:(DE-He78)HD01-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:35331942},
      doi          = {10.1016/j.cgh.2022.03.013},
      url          = {https://inrepo02.dkfz.de/record/179281},
}