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000179294 1001_ $$00000-0002-0039-2425$$aLegg, Meera$$b0
000179294 245__ $$aThe Association between Sleep Quality and Fatigue in Colorectal Cancer Survivors up until Two Years after Treatment: A Cross-Sectional and Longitudinal Analysis.
000179294 260__ $$aBasel$$bMDPI$$c2022
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000179294 520__ $$aFatigue is a distressing complaint with high detriment to quality of life that persists in one-third of colorectal cancer survivors after cancer treatment. Previous studies in mixed groups of cancer patients have suggested sleep quality is associated with fatigue. We aimed to investigate this association in colorectal cancer survivors up until two years post-treatment. Data on n = 388 stage I-III colorectal cancer patients were utilized from the EnCoRe study. Sleep quality and fatigue were measured at 6 weeks and 6, 12, and 24 months post-treatment. Sleep quality was measured using the Pittsburgh Sleep Quality Index (cross-sectional analysis only) and the single-item insomnia scale from the EORTC QLQ-C30. Fatigue was measured by the Checklist Individual Strength. Linear and mixed-model regression analyses analysed associations between sleep quality and fatigue cross-sectionally and longitudinally. Longitudinal analysis revealed worsening sleep quality over time was significantly associated with increased levels of fatigue over time (β per 0.5 SD increase in the EORTC-insomnia score = 2.56, 95% Cl: 1.91, 3.22). Significant cross-sectional associations were observed between worse sleep quality and higher levels of fatigue at all time points. Worse sleep quality in colorectal cancer patients was associated with higher levels of fatigue during the first two years post-treatment.
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000179294 650_7 $$2Other$$acancer
000179294 650_7 $$2Other$$acolorectal
000179294 650_7 $$2Other$$afatigue
000179294 650_7 $$2Other$$ainsomnia
000179294 650_7 $$2Other$$apatients
000179294 650_7 $$2Other$$aquality of life
000179294 650_7 $$2Other$$asleep
000179294 7001_ $$00000-0001-8424-9142$$aMeertens, Ree M$$b1
000179294 7001_ $$00000-0002-9402-2029$$avan Roekel, Eline$$b2
000179294 7001_ $$aBreukink, Stéphanie O$$b3
000179294 7001_ $$aJanssen, Maryska L$$b4
000179294 7001_ $$00000-0001-6666-8773$$aKeulen, Eric T P$$b5
000179294 7001_ $$0P:(DE-He78)a0c2037d9054be26907a05ae520d5756$$aSteindorf, Karen$$b6$$udkfz
000179294 7001_ $$aWeijenberg, Matty P$$b7
000179294 7001_ $$00000-0002-5558-1258$$aBours, Martijn$$b8
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