AU  - Kharazmi, Elhamalsadat
AU  - Sundquist, Kristina
AU  - Sundquist, Jan
AU  - Fallah, Mahdi
AU  - Bermejo, Justo Lorenzo
TI  - Risk of Gynecological Cancers in Cholecystectomized Women: A Large Nationwide Cohort Study.
JO  - Cancers
VL  - 14
IS  - 6
SN  - 2072-6694
CY  - Basel
M1  - DKFZ-2022-00577
SP  - 1484
PY  - 2022
N1  - #EA:C120#
AB  - Background: Gallstones affect women more frequently than men, and symptomatic gallstones are increasingly treated with surgical removal of the gallbladder (cholecystectomy). Breast, endometrial, and ovarian cancer share several risk factors with gallstones, including overweight, obesity, and exposure to female sex hormones. We intended to assess the association between cholecystectomy and female cancer risk, which has not been comprehensively investigated. Methods: We investigated the risk of female cancers after cholecystectomy leveraging the Swedish Cancer, Population, Patient, and Death registries. Standardized incidence ratios (SIRs) adjusted for age, calendar period, socioeconomic status, and residential area were used to compare cancer risk in cholecystectomized and non-cholecystectomized women. Results: During a median follow-up of 11 years, 325,106 cholecystectomized women developed 10,431 primary breast, 2888 endometrial, 1577 ovarian, and 705 cervical cancers. The risk of ovarian cancer was increased by 35
KW  - breast cancer (Other)
KW  - cervical cancer (Other)
KW  - cholecystectomy (Other)
KW  - endometrial cancer (Other)
KW  - gallbladder surgery (Other)
KW  - large nationwide cohort (Other)
KW  - ovarian cancer (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:35326635
C2  - pmc:PMC8946708
DO  - DOI:10.3390/cancers14061484
UR  - https://inrepo02.dkfz.de/record/179295
ER  -