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| Home > Publications database > Incidence and survival estimates for patients with myelodysplastic syndrome in the early 21st century: no evidence of improvement over time. > print |
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| 005 | 20240229145539.0 | ||
| 024 | 7 | _ | |a 10.1080/10428194.2022.2053529 |2 doi |
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| 100 | 1 | _ | |a Pulte, Dianne |0 P:(DE-He78)3772dc9cbbc020fbc52b5f63f1dc1e96 |b 0 |e First author |u dkfz |
| 245 | _ | _ | |a Incidence and survival estimates for patients with myelodysplastic syndrome in the early 21st century: no evidence of improvement over time. |
| 260 | _ | _ | |a London [u.a.] |c 2022 |b Taylor & Francis Group |
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| 520 | _ | _ | |a We examine changes in population level incidence and survival of patients diagnosed with myelodysplastic syndrome (MDS) in the United States in 2001-2016. Data were extracted from the Surveillance, Epidemiology, and End Results (SEER)-18 database. Period analysis was used to calculate one-, two-, and five-year survival. The incidence peaked at 5.6 per 100,000 in 2010 then decreased to 3.9 by 2016, with a decrease in the diagnoses of refractory anemia (RA) and RA with ringed sideroblasts (RARS) and a relative increase in RA with excess blasts (RAEB). Overall, one-, two-, and five-year relative survival decreased over time, going from 74.3%, 60.9%, and 42.3%, respectively, in 2008-2010 to 70.9%, 55.9%, and 37.6%, respectively, in 2014-2016. When survival was examined by histology, patients with RA/RARS and RAEB had similar survival expectations in 2008-2010 versus 2014-2016 and a decrease was observed for 5q-MDS. Our results highlight the need for new treatment options in MDS. |
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| 650 | _ | 7 | |a Myelodysplastic syndromes |2 Other |
| 650 | _ | 7 | |a incidence |2 Other |
| 650 | _ | 7 | |a period analysis |2 Other |
| 650 | _ | 7 | |a survival analysis |2 Other |
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| 773 | _ | _ | |a 10.1080/10428194.2022.2053529 |g p. 1 - 6 |0 PERI:(DE-600)2030637-4 |n 8 |p 1964-1969 |t Leukemia and lymphoma |v 63 |y 2022 |x 1026-8022 |
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