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000179337 041__ $$aEnglish
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000179337 1001_ $$aAlcala, Karine$$b0
000179337 245__ $$aThe relationship between blood pressure and risk of renal cell carcinoma.
000179337 260__ $$aOxford$$bOxford Univ. Press$$c2022
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000179337 500__ $$a2022 Aug 10;51(4):1317-1327
000179337 520__ $$aThe relation between blood pressure and kidney cancer risk is well established but complex and different study designs have reported discrepant findings on the relative importance of diastolic blood pressure (DBP) and systolic blood pressure (SBP). In this study, we sought to describe the temporal relation between diastolic and SBP with renal cell carcinoma (RCC) risk in detail.Our study involved two prospective cohorts: the European Prospective Investigation into Cancer and Nutrition study and UK Biobank, including >700 000 participants and 1692 incident RCC cases. Risk analyses were conducted using flexible parametric survival models for DBP and SBP both separately as well as with mutuality adjustment and then adjustment for extended risk factors. We also carried out univariable and multivariable Mendelian randomization (MR) analyses (DBP: ninstruments = 251, SBP: ninstruments = 213) to complement the analyses of measured DBP and SBP.In the univariable analysis, we observed clear positive associations with RCC risk for both diastolic and SBP when measured ≥5 years before diagnosis and suggestive evidence for a stronger risk association in the year leading up to diagnosis. In mutually adjusted analysis, the long-term risk association of DBP remained, with a hazard ratio (HR) per standard deviation increment 10 years before diagnosis (HR10y) of 1.20 (95% CI: 1.10-1.30), whereas the association of SBP was attenuated (HR10y: 1.00, 95% CI: 0.91-1.10). In the complementary multivariable MR analysis, we observed an odds ratio for a 1-SD increment (ORsd) of 1.34 (95% CI: 1.08-1.67) for genetically predicted DBP and 0.70 (95% CI: 0.56-0.88) for genetically predicted SBP.The results of this observational and MR study are consistent with an important role of DBP in RCC aetiology. The relation between SBP and RCC risk was less clear but does not appear to be independent of DBP.
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000179337 650_7 $$2Other$$aMendelian randomization
000179337 650_7 $$2Other$$aRCC
000179337 650_7 $$2Other$$adiastolic blood pressure
000179337 650_7 $$2Other$$akidney cancer
000179337 650_7 $$2Other$$asystolic blood pressure
000179337 7001_ $$aMariosa, Daniela$$b1
000179337 7001_ $$aSmith-Byrne, Karl$$b2
000179337 7001_ $$aNasrollahzadeh Nesheli, Dariush$$b3
000179337 7001_ $$aCarreras-Torres, Robert$$b4
000179337 7001_ $$aArdanaz Aicua, Eva$$b5
000179337 7001_ $$aBondonno, Nicola P$$b6
000179337 7001_ $$aBonet, Catalina$$b7
000179337 7001_ $$00000-0002-7054-0905$$aBrunström, Mattias$$b8
000179337 7001_ $$aBueno-de-Mesquita, Bas$$b9
000179337 7001_ $$aChirlaque, María-Dolores$$b10
000179337 7001_ $$00000-0001-9219-4436$$aChristakoudi, Sofia$$b11
000179337 7001_ $$00000-0001-6517-1300$$aHeath, Alicia K$$b12
000179337 7001_ $$0P:(DE-He78)4b2dc91c9d1ac33a1c0e0777d0c1697a$$aKaaks, Rudolf$$b13$$udkfz
000179337 7001_ $$0P:(DE-He78)fb68a9386399d72d84f7f34cfc6048b4$$aKatzke, Verena$$b14$$udkfz
000179337 7001_ $$00000-0003-0122-8624$$aKrogh, Vittorio$$b15
000179337 7001_ $$aLjungberg, Börje$$b16
000179337 7001_ $$aMartin, Richard M$$b17
000179337 7001_ $$aMay, Anne$$b18
000179337 7001_ $$aMelander, Olle$$b19
000179337 7001_ $$aPalli, Domenico$$b20
000179337 7001_ $$aRodriguez-Barranco, Miguel$$b21
000179337 7001_ $$00000-0002-8008-5096$$aSacerdote, Carlotta$$b22
000179337 7001_ $$00000-0002-0904-0557$$aStocks, Tanja$$b23
000179337 7001_ $$00000-0003-4385-2097$$aTjønneland, Anne$$b24
000179337 7001_ $$aTravis, Ruth C$$b25
000179337 7001_ $$00000-0003-4082-8163$$aVermeulen, Roel$$b26
000179337 7001_ $$00000-0002-2324-3393$$aChanock, Stephen$$b27
000179337 7001_ $$aPurdue, Mark$$b28
000179337 7001_ $$00000-0003-2237-0128$$aWeiderpass, Elisabete$$b29
000179337 7001_ $$aMuller, David$$b30
000179337 7001_ $$aBrennan, Paul$$b31
000179337 7001_ $$00000-0002-3116-5081$$aJohansson, Mattias$$b32
000179337 773__ $$0PERI:(DE-600)1494592-7$$a10.1093/ije/dyac042$$n4$$p1317-1327$$tInternational journal of epidemiology$$v51$$x0300-5771$$y2022
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