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@ARTICLE{Alcala:179337,
      author       = {K. Alcala and D. Mariosa and K. Smith-Byrne and D.
                      Nasrollahzadeh Nesheli and R. Carreras-Torres and E. Ardanaz
                      Aicua and N. P. Bondonno and C. Bonet and M. Brunström and
                      B. Bueno-de-Mesquita and M.-D. Chirlaque and S. Christakoudi
                      and A. K. Heath and R. Kaaks$^*$ and V. Katzke$^*$ and V.
                      Krogh and B. Ljungberg and R. M. Martin and A. May and O.
                      Melander and D. Palli and M. Rodriguez-Barranco and C.
                      Sacerdote and T. Stocks and A. Tjønneland and R. C. Travis
                      and R. Vermeulen and S. Chanock and M. Purdue and E.
                      Weiderpass and D. Muller and P. Brennan and M. Johansson},
      title        = {{T}he relationship between blood pressure and risk of renal
                      cell carcinoma.},
      journal      = {International journal of epidemiology},
      volume       = {51},
      number       = {4},
      issn         = {0300-5771},
      address      = {Oxford},
      publisher    = {Oxford Univ. Press},
      reportid     = {DKFZ-2022-00603},
      pages        = {1317-1327},
      year         = {2022},
      note         = {2022 Aug 10;51(4):1317-1327},
      abstract     = {The relation between blood pressure and kidney cancer risk
                      is well established but complex and different study designs
                      have reported discrepant findings on the relative importance
                      of diastolic blood pressure (DBP) and systolic blood
                      pressure (SBP). In this study, we sought to describe the
                      temporal relation between diastolic and SBP with renal cell
                      carcinoma (RCC) risk in detail.Our study involved two
                      prospective cohorts: the European Prospective Investigation
                      into Cancer and Nutrition study and UK Biobank, including
                      >700 000 participants and 1692 incident RCC cases. Risk
                      analyses were conducted using flexible parametric survival
                      models for DBP and SBP both separately as well as with
                      mutuality adjustment and then adjustment for extended risk
                      factors. We also carried out univariable and multivariable
                      Mendelian randomization (MR) analyses (DBP: ninstruments =
                      251, SBP: ninstruments = 213) to complement the analyses of
                      measured DBP and SBP.In the univariable analysis, we
                      observed clear positive associations with RCC risk for both
                      diastolic and SBP when measured ≥5 years before diagnosis
                      and suggestive evidence for a stronger risk association in
                      the year leading up to diagnosis. In mutually adjusted
                      analysis, the long-term risk association of DBP remained,
                      with a hazard ratio (HR) per standard deviation increment 10
                      years before diagnosis (HR10y) of 1.20 $(95\%$ CI:
                      1.10-1.30), whereas the association of SBP was attenuated
                      (HR10y: 1.00, $95\%$ CI: 0.91-1.10). In the complementary
                      multivariable MR analysis, we observed an odds ratio for a
                      1-SD increment (ORsd) of 1.34 $(95\%$ CI: 1.08-1.67) for
                      genetically predicted DBP and 0.70 $(95\%$ CI: 0.56-0.88)
                      for genetically predicted SBP.The results of this
                      observational and MR study are consistent with an important
                      role of DBP in RCC aetiology. The relation between SBP and
                      RCC risk was less clear but does not appear to be
                      independent of DBP.},
      keywords     = {Mendelian randomization (Other) / RCC (Other) / diastolic
                      blood pressure (Other) / kidney cancer (Other) / systolic
                      blood pressure (Other)},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:35312764},
      doi          = {10.1093/ije/dyac042},
      url          = {https://inrepo02.dkfz.de/record/179337},
}