%0 Journal Article
%A Hintz, Lisa
%A Glowa, Christin
%A Saager, Maria
%A Euler-Lange, Rosemarie
%A Peschke, Peter
%A Brons, Stephan
%A Grün, Rebecca
%A Scholz, Michael
%A Mein, Stewart
%A Mairani, Andrea
%A Debus, Jürgen
%A Karger, Christian
%T Relative biological effectiveness of single and split helium ion doses in the rat spinal cord increases strongly with linear energy transfer.
%J Radiotherapy and oncology
%V 170
%@ 0167-8140
%C Amsterdam [u.a.]
%I Elsevier Science
%M DKFZ-2022-00643
%P 224-230
%D 2022
%Z #EA:E040#LA:E040# /  2022 May;170:224-230
%X Determination of the relative biological effectiveness (RBE) of helium ions as a function of linear energy transfer (LET) for single and split doses using the rat cervical spinal cord as model system for late-responding normal tissue.The rat cervical spinal cord was irradiated at four different positions within a 6 cm spread-out Bragg-peak (SOBP) (LET 2.9, 9.4, 14.4 and 20.7 keV/µm) using increasing levels of single or split doses of helium ions. Dose-response curves were determined and based on TD50-values (dose at 50
%K Helium ion radiotherapy (Other)
%K Late normal tissue effects (Other)
%K Linear energy transfer (LET) (Other)
%K Local effect model (LEM) (Other)
%K Modified Microdosimetric kinetic model (mMKM) (Other)
%K Myelopathy (Other)
%K Protons (Other)
%K Rat spinal cord (Other)
%K Relative biological effectiveness (RBE) (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:35367526
%R 10.1016/j.radonc.2022.03.017
%U https://inrepo02.dkfz.de/record/179392