TY  - JOUR
AU  - Hintz, Lisa
AU  - Glowa, Christin
AU  - Saager, Maria
AU  - Euler-Lange, Rosemarie
AU  - Peschke, Peter
AU  - Brons, Stephan
AU  - Grün, Rebecca
AU  - Scholz, Michael
AU  - Mein, Stewart
AU  - Mairani, Andrea
AU  - Debus, Jürgen
AU  - Karger, Christian
TI  - Relative biological effectiveness of single and split helium ion doses in the rat spinal cord increases strongly with linear energy transfer.
JO  - Radiotherapy and oncology
VL  - 170
SN  - 0167-8140
CY  - Amsterdam [u.a.]
PB  - Elsevier Science
M1  - DKFZ-2022-00643
SP  - 224-230
PY  - 2022
N1  - #EA:E040#LA:E040# /  2022 May;170:224-230
AB  - Determination of the relative biological effectiveness (RBE) of helium ions as a function of linear energy transfer (LET) for single and split doses using the rat cervical spinal cord as model system for late-responding normal tissue.The rat cervical spinal cord was irradiated at four different positions within a 6 cm spread-out Bragg-peak (SOBP) (LET 2.9, 9.4, 14.4 and 20.7 keV/µm) using increasing levels of single or split doses of helium ions. Dose-response curves were determined and based on TD50-values (dose at 50
KW  - Helium ion radiotherapy (Other)
KW  - Late normal tissue effects (Other)
KW  - Linear energy transfer (LET) (Other)
KW  - Local effect model (LEM) (Other)
KW  - Modified Microdosimetric kinetic model (mMKM) (Other)
KW  - Myelopathy (Other)
KW  - Protons (Other)
KW  - Rat spinal cord (Other)
KW  - Relative biological effectiveness (RBE) (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:35367526
DO  - DOI:10.1016/j.radonc.2022.03.017
UR  - https://inrepo02.dkfz.de/record/179392
ER  -