TY  - JOUR
AU  - Zhu, Anna
AU  - Kuznia, Sabine
AU  - Niedermaier, Tobias
AU  - Holleczek, Bernd
AU  - Schöttker, Ben
AU  - Brenner, Hermann
TI  - Vitamin D-binding protein, total, 'non-bioavailable', bioavailable, and free 25-hydroxyvitamin D, and mortality in a large population-based cohort of older adults.
JO  - Journal of internal medicine
VL  - 292
IS  - 3
SN  - 0001-6101
CY  - Oxford [u.a.]
PB  - Wiley-Blackwell
M1  - DKFZ-2022-00656
SP  - 463-476
PY  - 2022
N1  - #EA:C070#LA:C070#LA:C120#  / 2022 Sep;292(3):463-476
AB  - Epidemiological studies consistently find low concentrations of 25-hydroxyvitamin D (25(OH)D) in blood to be associated with increased mortality, and a recent large-scale Mendelian randomization study strongly supports suggestions of a causal relationship among individuals with low vitamin D status. Evolving evidence suggested that bioavailable or free 25(OH)D may better predict mortality. We aimed to compare the prognostic values of vitamin D-binding protein (VDBP), total, bioavailable, complementary 'non-bioavailable', and free 25(OH)D for total and cause-specific mortality in a large population-based cohort study of older adults from Germany.Bioavailable, complementary non-bioavailable, and free 25(OH)D concentrations were calculated among 5899 participants aged 50-75 years, based on serum concentrations of total 25(OH)D, VDBP, and albumin. The cohort was followed with respect to total and cause-specific mortality from recruitment in 2001-2002 up to the end of 2018. Multivariable Cox proportional hazards regression models were used to assess the associations between various vitamin D biomarkers and mortality, and further stratified by vitamin D status.During a median follow-up of 17.1 years, 1739 participants died, of whom 575, 584, and 94 died of cardiovascular diseases, cancer, and respiratory diseases, respectively. Very similar inverse associations with total mortality (Hazard ratio (HR) per standard deviation decrease: 1.17, 95
KW  - bioavailable 25(OH)D (Other)
KW  - free 25(OH)D (Other)
KW  - mortality (Other)
KW  - vitamin D-binding protein (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:35373871
DO  - DOI:10.1111/joim.13494
UR  - https://inrepo02.dkfz.de/record/179414
ER  -