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@ARTICLE{Zhu:179414,
      author       = {A. Zhu$^*$ and S. Kuznia$^*$ and T. Niedermaier$^*$ and B.
                      Holleczek and B. Schöttker$^*$ and H. Brenner$^*$},
      title        = {{V}itamin {D}-binding protein, total, 'non-bioavailable',
                      bioavailable, and free 25-hydroxyvitamin {D}, and mortality
                      in a large population-based cohort of older adults.},
      journal      = {Journal of internal medicine},
      volume       = {292},
      number       = {3},
      issn         = {0001-6101},
      address      = {Oxford [u.a.]},
      publisher    = {Wiley-Blackwell},
      reportid     = {DKFZ-2022-00656},
      pages        = {463-476},
      year         = {2022},
      note         = {#EA:C070#LA:C070#LA:C120# / 2022 Sep;292(3):463-476},
      abstract     = {Epidemiological studies consistently find low
                      concentrations of 25-hydroxyvitamin D (25(OH)D) in blood to
                      be associated with increased mortality, and a recent
                      large-scale Mendelian randomization study strongly supports
                      suggestions of a causal relationship among individuals with
                      low vitamin D status. Evolving evidence suggested that
                      bioavailable or free 25(OH)D may better predict mortality.
                      We aimed to compare the prognostic values of vitamin
                      D-binding protein (VDBP), total, bioavailable, complementary
                      'non-bioavailable', and free 25(OH)D for total and
                      cause-specific mortality in a large population-based cohort
                      study of older adults from Germany.Bioavailable,
                      complementary non-bioavailable, and free 25(OH)D
                      concentrations were calculated among 5899 participants aged
                      50-75 years, based on serum concentrations of total 25(OH)D,
                      VDBP, and albumin. The cohort was followed with respect to
                      total and cause-specific mortality from recruitment in
                      2001-2002 up to the end of 2018. Multivariable Cox
                      proportional hazards regression models were used to assess
                      the associations between various vitamin D biomarkers and
                      mortality, and further stratified by vitamin D status.During
                      a median follow-up of 17.1 years, 1739 participants died, of
                      whom 575, 584, and 94 died of cardiovascular diseases,
                      cancer, and respiratory diseases, respectively. Very similar
                      inverse associations with total mortality (Hazard ratio (HR)
                      per standard deviation decrease: 1.17, $95\%$ CI: 1.11, 1.24
                      for total 25(OH)D; HR: 1.14, $95\%$ CI: 1.08, 1.21 for
                      bioavailable 25(OH)D; HR: 1.12, $95\%$ CI: 1.06, 1.18 for
                      free 25(OH)D) and cause-specific mortalities were seen for
                      all biomarkers of vitamin D status. The strongest
                      associations were consistently seen for respiratory
                      mortality. These inverse associations were strongest among
                      participants with low vitamin D levels (<50 nmol/L). No
                      significant associations were seen between VDBP and
                      mortality.Total, non-bioavailable, bioavailable, and free
                      25(OH)D showed very similar inverse associations with total
                      and cause-specific mortality, which were strongest among
                      those with low vitamin D status in this large
                      population-based cohort. This article is protected by
                      copyright. All rights reserved.},
      keywords     = {bioavailable 25(OH)D (Other) / free 25(OH)D (Other) /
                      mortality (Other) / vitamin D-binding protein (Other)},
      cin          = {C070 / C120 / HD01},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331 / I:(DE-He78)C120-20160331 /
                      I:(DE-He78)HD01-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:35373871},
      doi          = {10.1111/joim.13494},
      url          = {https://inrepo02.dkfz.de/record/179414},
}