%0 Journal Article
%A Cheng, Ting-Yuan David
%A Ilozumba, Mmadili N
%A Balavarca, Yesilda
%A Neuhouser, Marian L
%A Miller, Joshua W
%A Beresford, Shirley A A
%A Zheng, Yingye
%A Song, Xiaoling
%A Duggan, David J
%A Toriola, Adetunji T
%A Bailey, Lynn B
%A Green, Ralph
%A Caudill, Marie A
%A Ulrich, Cornelia M
%T Associations between Genetic Variants and Blood Biomarkers of One-Carbon Metabolism in Postmenopausal Women from the Women's Health Initiative Observational Study.
%J The journal of nutrition
%V 152
%N 4
%@ 0022-3166
%C Bethesda, Md.
%I Oxford University Press
%M DKFZ-2022-00663
%P 1099 - 1106
%D 2022
%X Genetic variation in one-carbon metabolism may affect nutrient concentrations and biological functions. However, data on genetic variants associated with blood biomarkers of one-carbon metabolism in US postmenopausal women are limited, and whether these associations were affected by the nationwide folic acid (FA) fortification program is unclear.We investigated associations between genetic variants and biomarkers of one-carbon metabolism using data from the Women's Health Initiative Observational Study.In 1573 non-Hispanic White (NHW) and 282 Black/African American, American Indian/Alaska Native, Asian/Pacific Islander, and Hispanic/Latino women aged 50-79 y, 288 nonsynonymous and tagging single-nucleotide variants (SNVs) were genotyped. RBC folate, plasma folate, pyridoxal-5'-phosphate (PLP), vitamin B-12, homocysteine, and cysteine concentrations were determined in 12-h fasting blood. Multivariable linear regression tested associations per variant allele and for an aggregated genetic risk score. Effect modifications before, during, and after nationwide FA fortification were examined.After correction for multiple comparisons, among NHW women, 5,10-methylenetetrahydrofolate reductase (MTHFR) rs1801133 (677C→T) variant T was associated with lower plasma folate (-13.0
%K Aged
%K Biomarkers
%K Carbon: metabolism
%K Female
%K Folic Acid
%K Genotype
%K Histocompatibility Antigens
%K Histone-Lysine N-Methyltransferase: genetics
%K Homocysteine
%K Humans
%K Methylenetetrahydrofolate Reductase (NADPH2): genetics
%K Methylenetetrahydrofolate Reductase (NADPH2): metabolism
%K Middle Aged
%K Postmenopause: genetics
%K Women's Health
%K MTHFR (Other)
%K folate (Other)
%K one-carbon metabolism (Other)
%K postmenopausal women (Other)
%K single-nucleotide variants (Other)
%K Biomarkers (NLM Chemicals)
%K Histocompatibility Antigens (NLM Chemicals)
%K Homocysteine (NLM Chemicals)
%K Carbon (NLM Chemicals)
%K Folic Acid (NLM Chemicals)
%K Methylenetetrahydrofolate Reductase (NADPH2) (NLM Chemicals)
%K EHMT2 protein, human (NLM Chemicals)
%K Histone-Lysine N-Methyltransferase (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:34967850
%2 pmc:PMC8971010
%R 10.1093/jn/nxab444
%U https://inrepo02.dkfz.de/record/179421