TY  - JOUR
AU  - Cheng, Ting-Yuan David
AU  - Ilozumba, Mmadili N
AU  - Balavarca, Yesilda
AU  - Neuhouser, Marian L
AU  - Miller, Joshua W
AU  - Beresford, Shirley A A
AU  - Zheng, Yingye
AU  - Song, Xiaoling
AU  - Duggan, David J
AU  - Toriola, Adetunji T
AU  - Bailey, Lynn B
AU  - Green, Ralph
AU  - Caudill, Marie A
AU  - Ulrich, Cornelia M
TI  - Associations between Genetic Variants and Blood Biomarkers of One-Carbon Metabolism in Postmenopausal Women from the Women's Health Initiative Observational Study.
JO  - The journal of nutrition
VL  - 152
IS  - 4
SN  - 0022-3166
CY  - Bethesda, Md.
PB  - Oxford University Press
M1  - DKFZ-2022-00663
SP  - 1099 - 1106
PY  - 2022
AB  - Genetic variation in one-carbon metabolism may affect nutrient concentrations and biological functions. However, data on genetic variants associated with blood biomarkers of one-carbon metabolism in US postmenopausal women are limited, and whether these associations were affected by the nationwide folic acid (FA) fortification program is unclear.We investigated associations between genetic variants and biomarkers of one-carbon metabolism using data from the Women's Health Initiative Observational Study.In 1573 non-Hispanic White (NHW) and 282 Black/African American, American Indian/Alaska Native, Asian/Pacific Islander, and Hispanic/Latino women aged 50-79 y, 288 nonsynonymous and tagging single-nucleotide variants (SNVs) were genotyped. RBC folate, plasma folate, pyridoxal-5'-phosphate (PLP), vitamin B-12, homocysteine, and cysteine concentrations were determined in 12-h fasting blood. Multivariable linear regression tested associations per variant allele and for an aggregated genetic risk score. Effect modifications before, during, and after nationwide FA fortification were examined.After correction for multiple comparisons, among NHW women, 5,10-methylenetetrahydrofolate reductase (MTHFR) rs1801133 (677C→T) variant T was associated with lower plasma folate (-13.0
KW  - Aged
KW  - Biomarkers
KW  - Carbon: metabolism
KW  - Female
KW  - Folic Acid
KW  - Genotype
KW  - Histocompatibility Antigens
KW  - Histone-Lysine N-Methyltransferase: genetics
KW  - Homocysteine
KW  - Humans
KW  - Methylenetetrahydrofolate Reductase (NADPH2): genetics
KW  - Methylenetetrahydrofolate Reductase (NADPH2): metabolism
KW  - Middle Aged
KW  - Postmenopause: genetics
KW  - Women's Health
KW  - MTHFR (Other)
KW  - folate (Other)
KW  - one-carbon metabolism (Other)
KW  - postmenopausal women (Other)
KW  - single-nucleotide variants (Other)
KW  - Biomarkers (NLM Chemicals)
KW  - Histocompatibility Antigens (NLM Chemicals)
KW  - Homocysteine (NLM Chemicals)
KW  - Carbon (NLM Chemicals)
KW  - Folic Acid (NLM Chemicals)
KW  - Methylenetetrahydrofolate Reductase (NADPH2) (NLM Chemicals)
KW  - EHMT2 protein, human (NLM Chemicals)
KW  - Histone-Lysine N-Methyltransferase (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:34967850
C2  - pmc:PMC8971010
DO  - DOI:10.1093/jn/nxab444
UR  - https://inrepo02.dkfz.de/record/179421
ER  -