%0 Journal Article
%A Fortuin-de Smidt, Melony C
%A Sewe, Maquins Odhiambo
%A Lassale, Camille
%A Weiderpass, Elisabete
%A Andersson, Jonas
%A Huerta, José María
%A Ekelund, Ulf
%A Aleksandrova, Krasimira
%A Tong, Tammy Yn
%A Dahm, Christina C
%A Tjønneland, Anne
%A Kyrø, Cecilie
%A Steindorf, Karen
%A Schulze, Matthias B
%A Katzke, Verena
%A Sacerdote, Carlotta
%A Agnoli, Claudia
%A Masala, Giovanna
%A Tumino, Rosario
%A Panico, Salvatore
%A Boer, Jolanda Ma
%A Onland-Moret, N Charlotte
%A Wendel-Vos, Gc Wanda
%A van der Schouw, Yvonne T
%A Borch, Kristin Benjaminsen
%A Agudo, Antonio
%A Petrova, Dafina
%A Chirlaque, María-Dolores
%A Conchi, Moreno-Iribas
%A Amiano, Pilar
%A Melander, Olle
%A Heath, Alicia K
%A Aune, Dagfinn
%A Forouhi, Nita G
%A Langenberg, Claudia
%A Brage, Soren
%A Riboli, Elio
%A Wareham, Nicholas J
%A Danesh, John
%A Butterworth, Adam S
%A Wennberg, Patrik
%T Physical activity attenuates but does not eliminate coronary heart disease risk amongst adults with risk factors: EPIC-CVD case-cohort study.
%J European journal of preventive cardiology
%V 29
%N 12
%@ 2047-4873
%C London [u.a.]
%I Sage Publ.
%M DKFZ-2022-00717
%P 1618-1629
%D 2022
%Z 2022 Sep 7;29(12):1618-1629
%X This study aimed to evaluate the association between physical activity and the incidence of coronary heart disease (CHD) in individuals with and without CHD risk factors.EPIC-CVD is a case-cohort study of 29 333 participants that included 13 582 incident CHD cases and a randomly selected sub-cohort nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Self-reported physical activity was summarized using the Cambridge physical activity index (inactive, moderately inactive, moderately active, and active). Participants were categorized into sub-groups based on the presence or the absence of the following risk factors: obesity (body mass index ≥30 kg/m2), hypercholesterolaemia (total cholesterol ≥6.2 mmol/L), history of diabetes, hypertension (self-reported or ≥140/90 mmHg), and current smoking. Prentice-weighted Cox regression was used to assess the association between physical activity and incident CHD events (non-fatal and fatal).Compared to inactive participants without the respective CHD risk factor (referent), excess CHD risk was highest in physically inactive and lowest in moderately active participants with CHD risk factors. Corresponding excess CHD risk estimates amongst those with obesity were 47
%K Case-cohort study (Other)
%K Coronary heart disease (Other)
%K Physical activity (Other)
%K Population preventable fraction (Other)
%K Risk factors (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:35403197
%R 10.1093/eurjpc/zwac055
%U https://inrepo02.dkfz.de/record/179539