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000179539 0247_ $$2doi$$a10.1093/eurjpc/zwac055
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000179539 0247_ $$2ISSN$$a2047-4873
000179539 0247_ $$2ISSN$$a2047-4881
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000179539 037__ $$aDKFZ-2022-00717
000179539 041__ $$aEnglish
000179539 082__ $$a610
000179539 1001_ $$00000-0003-3488-7781$$aFortuin-de Smidt, Melony C$$b0
000179539 245__ $$aPhysical activity attenuates but does not eliminate coronary heart disease risk amongst adults with risk factors: EPIC-CVD case-cohort study.
000179539 260__ $$aLondon [u.a.]$$bSage Publ.$$c2022
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000179539 500__ $$a2022 Sep 7;29(12):1618-1629
000179539 520__ $$aThis study aimed to evaluate the association between physical activity and the incidence of coronary heart disease (CHD) in individuals with and without CHD risk factors.EPIC-CVD is a case-cohort study of 29 333 participants that included 13 582 incident CHD cases and a randomly selected sub-cohort nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Self-reported physical activity was summarized using the Cambridge physical activity index (inactive, moderately inactive, moderately active, and active). Participants were categorized into sub-groups based on the presence or the absence of the following risk factors: obesity (body mass index ≥30 kg/m2), hypercholesterolaemia (total cholesterol ≥6.2 mmol/L), history of diabetes, hypertension (self-reported or ≥140/90 mmHg), and current smoking. Prentice-weighted Cox regression was used to assess the association between physical activity and incident CHD events (non-fatal and fatal).Compared to inactive participants without the respective CHD risk factor (referent), excess CHD risk was highest in physically inactive and lowest in moderately active participants with CHD risk factors. Corresponding excess CHD risk estimates amongst those with obesity were 47% [95% confidence interval (CI) 32-64%] and 21% (95%CI 2-44%), with hypercholesterolaemia were 80% (95%CI 55-108%) and 48% (95%CI 22-81%), with hypertension were 80% (95%CI 65-96%) and 49% (95%CI 28-74%), with diabetes were 142% (95%CI 63-260%), and 100% (95%CI 32-204%), and amongst smokers were 152% (95%CI 122-186%) and 109% (95%CI 74-150%).In people with CHD risk factors, moderate physical activity, equivalent to 40 mins of walking per day, attenuates but does not completely offset CHD risk.
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000179539 650_7 $$2Other$$aCase-cohort study
000179539 650_7 $$2Other$$aCoronary heart disease
000179539 650_7 $$2Other$$aPhysical activity
000179539 650_7 $$2Other$$aPopulation preventable fraction
000179539 650_7 $$2Other$$aRisk factors
000179539 7001_ $$aSewe, Maquins Odhiambo$$b1
000179539 7001_ $$aLassale, Camille$$b2
000179539 7001_ $$aWeiderpass, Elisabete$$b3
000179539 7001_ $$aAndersson, Jonas$$b4
000179539 7001_ $$aHuerta, José María$$b5
000179539 7001_ $$aEkelund, Ulf$$b6
000179539 7001_ $$00000-0002-1275-1827$$aAleksandrova, Krasimira$$b7
000179539 7001_ $$00000-0002-0284-8959$$aTong, Tammy Yn$$b8
000179539 7001_ $$aDahm, Christina C$$b9
000179539 7001_ $$00000-0003-4385-2097$$aTjønneland, Anne$$b10
000179539 7001_ $$00000-0002-9083-8960$$aKyrø, Cecilie$$b11
000179539 7001_ $$0P:(DE-He78)a0c2037d9054be26907a05ae520d5756$$aSteindorf, Karen$$b12$$udkfz
000179539 7001_ $$aSchulze, Matthias B$$b13
000179539 7001_ $$0P:(DE-He78)fb68a9386399d72d84f7f34cfc6048b4$$aKatzke, Verena$$b14$$udkfz
000179539 7001_ $$00000-0002-8008-5096$$aSacerdote, Carlotta$$b15
000179539 7001_ $$00000-0003-4472-1179$$aAgnoli, Claudia$$b16
000179539 7001_ $$00000-0002-5758-9069$$aMasala, Giovanna$$b17
000179539 7001_ $$00000-0003-2666-414X$$aTumino, Rosario$$b18
000179539 7001_ $$00000-0002-5498-8312$$aPanico, Salvatore$$b19
000179539 7001_ $$aBoer, Jolanda Ma$$b20
000179539 7001_ $$aOnland-Moret, N Charlotte$$b21
000179539 7001_ $$aWendel-Vos, Gc Wanda$$b22
000179539 7001_ $$avan der Schouw, Yvonne T$$b23
000179539 7001_ $$aBorch, Kristin Benjaminsen$$b24
000179539 7001_ $$aAgudo, Antonio$$b25
000179539 7001_ $$aPetrova, Dafina$$b26
000179539 7001_ $$aChirlaque, María-Dolores$$b27
000179539 7001_ $$aConchi, Moreno-Iribas$$b28
000179539 7001_ $$aAmiano, Pilar$$b29
000179539 7001_ $$aMelander, Olle$$b30
000179539 7001_ $$aHeath, Alicia K$$b31
000179539 7001_ $$00000-0002-4533-1722$$aAune, Dagfinn$$b32
000179539 7001_ $$00000-0002-5041-248X$$aForouhi, Nita G$$b33
000179539 7001_ $$aLangenberg, Claudia$$b34
000179539 7001_ $$aBrage, Soren$$b35
000179539 7001_ $$00000-0001-6795-6080$$aRiboli, Elio$$b36
000179539 7001_ $$aWareham, Nicholas J$$b37
000179539 7001_ $$aDanesh, John$$b38
000179539 7001_ $$aButterworth, Adam S$$b39
000179539 7001_ $$aWennberg, Patrik$$b40
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