TY  - JOUR
AU  - Fortuin-de Smidt, Melony C
AU  - Sewe, Maquins Odhiambo
AU  - Lassale, Camille
AU  - Weiderpass, Elisabete
AU  - Andersson, Jonas
AU  - Huerta, José María
AU  - Ekelund, Ulf
AU  - Aleksandrova, Krasimira
AU  - Tong, Tammy Yn
AU  - Dahm, Christina C
AU  - Tjønneland, Anne
AU  - Kyrø, Cecilie
AU  - Steindorf, Karen
AU  - Schulze, Matthias B
AU  - Katzke, Verena
AU  - Sacerdote, Carlotta
AU  - Agnoli, Claudia
AU  - Masala, Giovanna
AU  - Tumino, Rosario
AU  - Panico, Salvatore
AU  - Boer, Jolanda Ma
AU  - Onland-Moret, N Charlotte
AU  - Wendel-Vos, Gc Wanda
AU  - van der Schouw, Yvonne T
AU  - Borch, Kristin Benjaminsen
AU  - Agudo, Antonio
AU  - Petrova, Dafina
AU  - Chirlaque, María-Dolores
AU  - Conchi, Moreno-Iribas
AU  - Amiano, Pilar
AU  - Melander, Olle
AU  - Heath, Alicia K
AU  - Aune, Dagfinn
AU  - Forouhi, Nita G
AU  - Langenberg, Claudia
AU  - Brage, Soren
AU  - Riboli, Elio
AU  - Wareham, Nicholas J
AU  - Danesh, John
AU  - Butterworth, Adam S
AU  - Wennberg, Patrik
TI  - Physical activity attenuates but does not eliminate coronary heart disease risk amongst adults with risk factors: EPIC-CVD case-cohort study.
JO  - European journal of preventive cardiology
VL  - 29
IS  - 12
SN  - 2047-4873
CY  - London [u.a.]
PB  - Sage Publ.
M1  - DKFZ-2022-00717
SP  - 1618-1629
PY  - 2022
N1  - 2022 Sep 7;29(12):1618-1629
AB  - This study aimed to evaluate the association between physical activity and the incidence of coronary heart disease (CHD) in individuals with and without CHD risk factors.EPIC-CVD is a case-cohort study of 29 333 participants that included 13 582 incident CHD cases and a randomly selected sub-cohort nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Self-reported physical activity was summarized using the Cambridge physical activity index (inactive, moderately inactive, moderately active, and active). Participants were categorized into sub-groups based on the presence or the absence of the following risk factors: obesity (body mass index ≥30 kg/m2), hypercholesterolaemia (total cholesterol ≥6.2 mmol/L), history of diabetes, hypertension (self-reported or ≥140/90 mmHg), and current smoking. Prentice-weighted Cox regression was used to assess the association between physical activity and incident CHD events (non-fatal and fatal).Compared to inactive participants without the respective CHD risk factor (referent), excess CHD risk was highest in physically inactive and lowest in moderately active participants with CHD risk factors. Corresponding excess CHD risk estimates amongst those with obesity were 47
KW  - Case-cohort study (Other)
KW  - Coronary heart disease (Other)
KW  - Physical activity (Other)
KW  - Population preventable fraction (Other)
KW  - Risk factors (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:35403197
DO  - DOI:10.1093/eurjpc/zwac055
UR  - https://inrepo02.dkfz.de/record/179539
ER  -