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@ARTICLE{FortuindeSmidt:179539,
      author       = {M. C. Fortuin-de Smidt and M. O. Sewe and C. Lassale and E.
                      Weiderpass and J. Andersson and J. M. Huerta and U. Ekelund
                      and K. Aleksandrova and T. Y. Tong and C. C. Dahm and A.
                      Tjønneland and C. Kyrø and K. Steindorf$^*$ and M. B.
                      Schulze and V. Katzke$^*$ and C. Sacerdote and C. Agnoli and
                      G. Masala and R. Tumino and S. Panico and J. M. Boer and N.
                      C. Onland-Moret and G. W. Wendel-Vos and Y. T. van der
                      Schouw and K. B. Borch and A. Agudo and D. Petrova and M.-D.
                      Chirlaque and M.-I. Conchi and P. Amiano and O. Melander and
                      A. K. Heath and D. Aune and N. G. Forouhi and C. Langenberg
                      and S. Brage and E. Riboli and N. J. Wareham and J. Danesh
                      and A. S. Butterworth and P. Wennberg},
      title        = {{P}hysical activity attenuates but does not eliminate
                      coronary heart disease risk amongst adults with risk
                      factors: {EPIC}-{CVD} case-cohort study.},
      journal      = {European journal of preventive cardiology},
      volume       = {29},
      number       = {12},
      issn         = {2047-4873},
      address      = {London [u.a.]},
      publisher    = {Sage Publ.},
      reportid     = {DKFZ-2022-00717},
      pages        = {1618-1629},
      year         = {2022},
      note         = {2022 Sep 7;29(12):1618-1629},
      abstract     = {This study aimed to evaluate the association between
                      physical activity and the incidence of coronary heart
                      disease (CHD) in individuals with and without CHD risk
                      factors.EPIC-CVD is a case-cohort study of 29 333
                      participants that included 13 582 incident CHD cases and a
                      randomly selected sub-cohort nested within the European
                      Prospective Investigation into Cancer and Nutrition (EPIC)
                      cohort. Self-reported physical activity was summarized using
                      the Cambridge physical activity index (inactive, moderately
                      inactive, moderately active, and active). Participants were
                      categorized into sub-groups based on the presence or the
                      absence of the following risk factors: obesity (body mass
                      index ≥30 kg/m2), hypercholesterolaemia (total cholesterol
                      ≥6.2 mmol/L), history of diabetes, hypertension
                      (self-reported or ≥140/90 mmHg), and current smoking.
                      Prentice-weighted Cox regression was used to assess the
                      association between physical activity and incident CHD
                      events (non-fatal and fatal).Compared to inactive
                      participants without the respective CHD risk factor
                      (referent), excess CHD risk was highest in physically
                      inactive and lowest in moderately active participants with
                      CHD risk factors. Corresponding excess CHD risk estimates
                      amongst those with obesity were $47\%$ $[95\%$ confidence
                      interval (CI) $32-64\%]$ and $21\%$ $(95\%CI$ $2-44\%),$
                      with hypercholesterolaemia were $80\%$ $(95\%CI$ $55-108\%)$
                      and $48\%$ $(95\%CI$ $22-81\%),$ with hypertension were
                      $80\%$ $(95\%CI$ $65-96\%)$ and $49\%$ $(95\%CI$ $28-74\%),$
                      with diabetes were $142\%$ $(95\%CI$ $63-260\%),$ and
                      $100\%$ $(95\%CI$ $32-204\%),$ and amongst smokers were
                      $152\%$ $(95\%CI$ $122-186\%)$ and $109\%$ $(95\%CI$
                      $74-150\%).In$ people with CHD risk factors, moderate
                      physical activity, equivalent to 40 mins of walking per day,
                      attenuates but does not completely offset CHD risk.},
      keywords     = {Case-cohort study (Other) / Coronary heart disease (Other)
                      / Physical activity (Other) / Population preventable
                      fraction (Other) / Risk factors (Other)},
      cin          = {C110 / C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C110-20160331 / I:(DE-He78)C020-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:35403197},
      doi          = {10.1093/eurjpc/zwac055},
      url          = {https://inrepo02.dkfz.de/record/179539},
}