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000179552 0247_ $$2doi$$a10.3390/nu14071437
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000179552 041__ $$aEnglish
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000179552 1001_ $$aSpurny, Manuela$$b0
000179552 245__ $$aChanges in Kidney Fat upon Dietary-Induced Weight Loss.
000179552 260__ $$aBasel$$bMDPI$$c2022
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000179552 520__ $$aAs the metabolic role of kidney fat remains unclear, we investigated the effects of dietary weight loss on kidney fat content (KFC) and its connection to kidney function and metabolism. Overweight or obese participants (n = 137) of a dietary intervention trial were classified into quartiles of weight loss in a post hoc manner. Kidney sinus (KSF) and cortex fat (KCF) were measured by magnetic resonance imaging at baseline, week 12 and week 50. Weight loss effects on KFC were evaluated by linear mixed models. Repeated measures correlations between KFC, other body fat measures and metabolic biomarkers were obtained. KSF, but not KCF, decreased significantly across weight loss quartiles at week 12 (quartile 4: -21.3%; p = 0.02) and 50 (-22.0%, p = 0.001), which remained significant after adjusting for VAT. There were smaller improvements regarding creatinine (-2.5%, p = 0.02) at week 12, but not week 50. KSF, but not KCF, correlated with visceral (rrm = 0.38) and subcutaneous fat volumes (rrm = 0.31) and liver fat content (rrm = 0.32), as well as diastolic blood pressure and biomarkers of lipid, glucose and liver metabolism. Dietary weight loss is associated with decreases in KSF, but not KCF, which suggests that KSF may be the metabolically relevant ectopic fat depot of the kidney. KSF may be targeted for obesity-related disease prevention.
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000179552 650_7 $$2Other$$abody composition
000179552 650_7 $$2Other$$adiet induced weight loss
000179552 650_7 $$2Other$$akidney fat content
000179552 650_7 $$2Other$$amagnetic resonance imaging
000179552 650_7 $$2Other$$aobesity
000179552 650_7 $$2Other$$aoverweight
000179552 650_7 $$2Other$$arenal sinus fat
000179552 650_7 $$2NLM Chemicals$$aBiomarkers
000179552 650_2 $$2MeSH$$aAdipose Tissue: metabolism
000179552 650_2 $$2MeSH$$aBiomarkers
000179552 650_2 $$2MeSH$$aHumans
000179552 650_2 $$2MeSH$$aKidney: metabolism
000179552 650_2 $$2MeSH$$aObesity: metabolism
000179552 650_2 $$2MeSH$$aOverweight: complications
000179552 650_2 $$2MeSH$$aWeight Loss: physiology
000179552 7001_ $$00000-0001-8504-0500$$aJiang, Yixin$$b1
000179552 7001_ $$0P:(DE-He78)b4004ee4b650b575447f59a4a0471312$$aSowah, Solomon$$b2
000179552 7001_ $$aNonnenmacher, Tobias$$b3
000179552 7001_ $$0P:(DE-He78)ceb74219d144ab5760a228e71440c5ca$$aSchübel, Ruth$$b4
000179552 7001_ $$aKirsten, Romy$$b5
000179552 7001_ $$0P:(DE-He78)79ab945544e5bc017a2317b6146ed3aa$$aJohnson, Theron$$b6$$udkfz
000179552 7001_ $$avon Stackelberg, Oyunbileg$$b7
000179552 7001_ $$aUlrich, Cornelia M$$b8
000179552 7001_ $$0P:(DE-He78)4b2dc91c9d1ac33a1c0e0777d0c1697a$$aKaaks, Rudolf$$b9$$udkfz
000179552 7001_ $$aKauczor, Hans-Ulrich$$b10
000179552 7001_ $$0P:(DE-He78)0907a10ba1dc8f53f04907f54f6fdcfe$$aKühn, Tilman$$b11
000179552 7001_ $$aNattenmüller, Johanna$$b12
000179552 773__ $$0PERI:(DE-600)2518386-2$$a10.3390/nu14071437$$gVol. 14, no. 7, p. 1437 -$$n7$$p1437$$tNutrients$$v14$$x2072-6643$$y2022
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000179552 9141_ $$y2022
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