TY  - JOUR
AU  - Spurny, Manuela
AU  - Jiang, Yixin
AU  - Sowah, Solomon
AU  - Nonnenmacher, Tobias
AU  - Schübel, Ruth
AU  - Kirsten, Romy
AU  - Johnson, Theron
AU  - von Stackelberg, Oyunbileg
AU  - Ulrich, Cornelia M
AU  - Kaaks, Rudolf
AU  - Kauczor, Hans-Ulrich
AU  - Kühn, Tilman
AU  - Nattenmüller, Johanna
TI  - Changes in Kidney Fat upon Dietary-Induced Weight Loss.
JO  - Nutrients
VL  - 14
IS  - 7
SN  - 2072-6643
CY  - Basel
PB  - MDPI
M1  - DKFZ-2022-00730
SP  - 1437
PY  - 2022
AB  - As the metabolic role of kidney fat remains unclear, we investigated the effects of dietary weight loss on kidney fat content (KFC) and its connection to kidney function and metabolism. Overweight or obese participants (n = 137) of a dietary intervention trial were classified into quartiles of weight loss in a post hoc manner. Kidney sinus (KSF) and cortex fat (KCF) were measured by magnetic resonance imaging at baseline, week 12 and week 50. Weight loss effects on KFC were evaluated by linear mixed models. Repeated measures correlations between KFC, other body fat measures and metabolic biomarkers were obtained. KSF, but not KCF, decreased significantly across weight loss quartiles at week 12 (quartile 4: -21.3
KW  - Adipose Tissue: metabolism
KW  - Biomarkers
KW  - Humans
KW  - Kidney: metabolism
KW  - Obesity: metabolism
KW  - Overweight: complications
KW  - Weight Loss: physiology
KW  - body composition (Other)
KW  - diet induced weight loss (Other)
KW  - kidney fat content (Other)
KW  - magnetic resonance imaging (Other)
KW  - obesity (Other)
KW  - overweight (Other)
KW  - renal sinus fat (Other)
KW  - Biomarkers (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:35406052
C2  - pmc:PMC9002806
DO  - DOI:10.3390/nu14071437
UR  - https://inrepo02.dkfz.de/record/179552
ER  -