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@ARTICLE{Spurny:179552,
      author       = {M. Spurny and Y. Jiang and S. Sowah$^*$ and T. Nonnenmacher
                      and R. Schübel$^*$ and R. Kirsten and T. Johnson$^*$ and O.
                      von Stackelberg and C. M. Ulrich and R. Kaaks$^*$ and H.-U.
                      Kauczor and T. Kühn$^*$ and J. Nattenmüller},
      title        = {{C}hanges in {K}idney {F}at upon {D}ietary-{I}nduced
                      {W}eight {L}oss.},
      journal      = {Nutrients},
      volume       = {14},
      number       = {7},
      issn         = {2072-6643},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {DKFZ-2022-00730},
      pages        = {1437},
      year         = {2022},
      abstract     = {As the metabolic role of kidney fat remains unclear, we
                      investigated the effects of dietary weight loss on kidney
                      fat content (KFC) and its connection to kidney function and
                      metabolism. Overweight or obese participants (n = 137) of a
                      dietary intervention trial were classified into quartiles of
                      weight loss in a post hoc manner. Kidney sinus (KSF) and
                      cortex fat (KCF) were measured by magnetic resonance imaging
                      at baseline, week 12 and week 50. Weight loss effects on KFC
                      were evaluated by linear mixed models. Repeated measures
                      correlations between KFC, other body fat measures and
                      metabolic biomarkers were obtained. KSF, but not KCF,
                      decreased significantly across weight loss quartiles at week
                      12 (quartile 4: $-21.3\%;$ p = 0.02) and 50 $(-22.0\%,$ p =
                      0.001), which remained significant after adjusting for VAT.
                      There were smaller improvements regarding creatinine
                      $(-2.5\%,$ p = 0.02) at week 12, but not week 50. KSF, but
                      not KCF, correlated with visceral (rrm = 0.38) and
                      subcutaneous fat volumes (rrm = 0.31) and liver fat content
                      (rrm = 0.32), as well as diastolic blood pressure and
                      biomarkers of lipid, glucose and liver metabolism. Dietary
                      weight loss is associated with decreases in KSF, but not
                      KCF, which suggests that KSF may be the metabolically
                      relevant ectopic fat depot of the kidney. KSF may be
                      targeted for obesity-related disease prevention.},
      keywords     = {Adipose Tissue: metabolism / Biomarkers / Humans / Kidney:
                      metabolism / Obesity: metabolism / Overweight: complications
                      / Weight Loss: physiology / body composition (Other) / diet
                      induced weight loss (Other) / kidney fat content (Other) /
                      magnetic resonance imaging (Other) / obesity (Other) /
                      overweight (Other) / renal sinus fat (Other) / Biomarkers
                      (NLM Chemicals)},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:35406052},
      pmc          = {pmc:PMC9002806},
      doi          = {10.3390/nu14071437},
      url          = {https://inrepo02.dkfz.de/record/179552},
}