000179556 001__ 179556
000179556 005__ 20240918080814.0
000179556 0247_ $$2doi$$a10.1038/s41598-022-10121-2
000179556 0247_ $$2pmid$$apmid:35418701
000179556 0247_ $$2pmc$$apmc:PMC9007944
000179556 0247_ $$2altmetric$$aaltmetric:126589623
000179556 037__ $$aDKFZ-2022-00734
000179556 041__ $$aEnglish
000179556 082__ $$a600
000179556 1001_ $$aWang, Xiaoliang$$b0
000179556 245__ $$aGenome-wide interaction analysis of menopausal hormone therapy use and breast cancer risk among 62,370 women.
000179556 260__ $$a[London]$$bMacmillan Publishers Limited, part of Springer Nature$$c2022
000179556 3367_ $$2DRIVER$$aarticle
000179556 3367_ $$2DataCite$$aOutput Types/Journal article
000179556 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1726639674_5616
000179556 3367_ $$2BibTeX$$aARTICLE
000179556 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000179556 3367_ $$00$$2EndNote$$aJournal Article
000179556 520__ $$aUse of menopausal hormone therapy (MHT) is associated with increased risk for breast cancer. However, the relevant mechanisms and its interaction with genetic variants are not fully understood. We conducted a genome-wide interaction analysis between MHT use and genetic variants for breast cancer risk in 27,585 cases and 34,785 controls from 26 observational studies. All women were post-menopausal and of European ancestry. Multivariable logistic regression models were used to test for multiplicative interactions between genetic variants and current MHT use. We considered interaction p-values < 5 × 10-8 as genome-wide significant, and p-values < 1 × 10-5 as suggestive. Linkage disequilibrium (LD)-based clumping was performed to identify independent candidate variants. None of the 9.7 million genetic variants tested for interactions with MHT use reached genome-wide significance. Only 213 variants, representing 18 independent loci, had p-values < 1 × 105. The strongest evidence was found for rs4674019 (p-value = 2.27 × 10-7), which showed genome-wide significant interaction (p-value = 3.8 × 10-8) with current MHT use when analysis was restricted to population-based studies only. Limiting the analyses to combined estrogen-progesterone MHT use only or to estrogen receptor (ER) positive cases did not identify any genome-wide significant evidence of interactions. In this large genome-wide SNP-MHT interaction study of breast cancer, we found no strong support for common genetic variants modifying the effect of MHT on breast cancer risk. These results suggest that common genetic variation has limited impact on the observed MHT-breast cancer risk association.
000179556 536__ $$0G:(DE-HGF)POF4-313$$a313 - Krebsrisikofaktoren und Prävention (POF4-313)$$cPOF4-313$$fPOF IV$$x0
000179556 588__ $$aDataset connected to CrossRef, PubMed, , Journals: inrepo02.dkfz.de
000179556 650_2 $$2MeSH$$aBreast
000179556 650_2 $$2MeSH$$aBreast Neoplasms: chemically induced
000179556 650_2 $$2MeSH$$aBreast Neoplasms: epidemiology
000179556 650_2 $$2MeSH$$aBreast Neoplasms: genetics
000179556 650_2 $$2MeSH$$aEstrogen Replacement Therapy: adverse effects
000179556 650_2 $$2MeSH$$aFemale
000179556 650_2 $$2MeSH$$aHormone Replacement Therapy: adverse effects
000179556 650_2 $$2MeSH$$aHumans
000179556 650_2 $$2MeSH$$aMale
000179556 650_2 $$2MeSH$$aMenopause
000179556 650_2 $$2MeSH$$aRisk Factors
000179556 7001_ $$0P:(DE-HGF)0$$aKapoor, Pooja Middha$$b1
000179556 7001_ $$aAuer, Paul L$$b2
000179556 7001_ $$aDennis, Joe$$b3
000179556 7001_ $$aDunning, Alison M$$b4
000179556 7001_ $$aWang, Qin$$b5
000179556 7001_ $$aLush, Michael$$b6
000179556 7001_ $$aMichailidou, Kyriaki$$b7
000179556 7001_ $$aBolla, Manjeet K$$b8
000179556 7001_ $$aAronson, Kristan J$$b9
000179556 7001_ $$aMurphy, Rachel A$$b10
000179556 7001_ $$aBrooks-Wilson, Angela$$b11
000179556 7001_ $$aLee, Derrick G$$b12
000179556 7001_ $$aCordina-Duverger, Emilie$$b13
000179556 7001_ $$aGuénel, Pascal$$b14
000179556 7001_ $$aTruong, Thérèse$$b15
000179556 7001_ $$aMulot, Claire$$b16
000179556 7001_ $$aTeras, Lauren R$$b17
000179556 7001_ $$aPatel, Alpa V$$b18
000179556 7001_ $$aDossus, Laure$$b19
000179556 7001_ $$0P:(DE-He78)4b2dc91c9d1ac33a1c0e0777d0c1697a$$aKaaks, Rudolf$$b20$$udkfz
000179556 7001_ $$aHoppe, Reiner$$b21
000179556 7001_ $$aLo, Wing-Yee$$b22
000179556 7001_ $$aBrüning, Thomas$$b23
000179556 7001_ $$0P:(DE-He78)537e07b3e57b16c7b214fc2242e4326b$$aHamann, Ute$$b24$$udkfz
000179556 7001_ $$aCzene, Kamila$$b25
000179556 7001_ $$aGabrielson, Marike$$b26
000179556 7001_ $$aHall, Per$$b27
000179556 7001_ $$aEriksson, Mikael$$b28
000179556 7001_ $$0P:(DE-He78)bce1fdec5ce564e2666156d96aeabec9$$aJung, Audrey$$b29$$udkfz
000179556 7001_ $$aBecher, Heiko$$b30
000179556 7001_ $$aCouch, Fergus J$$b31
000179556 7001_ $$aLarson, Nicole L$$b32
000179556 7001_ $$aOlson, Janet E$$b33
000179556 7001_ $$aRuddy, Kathryn J$$b34
000179556 7001_ $$aGiles, Graham G$$b35
000179556 7001_ $$aMacInnis, Robert J$$b36
000179556 7001_ $$aSouthey, Melissa C$$b37
000179556 7001_ $$aLe Marchand, Loic$$b38
000179556 7001_ $$aWilkens, Lynne R$$b39
000179556 7001_ $$aHaiman, Christopher A$$b40
000179556 7001_ $$aOlsson, Håkan$$b41
000179556 7001_ $$aAugustinsson, Annelie$$b42
000179556 7001_ $$aKrüger, Ute$$b43
000179556 7001_ $$aWagner, Philippe$$b44
000179556 7001_ $$aScott, Christopher$$b45
000179556 7001_ $$aWinham, Stacey J$$b46
000179556 7001_ $$aVachon, Celine M$$b47
000179556 7001_ $$aPerou, Charles M$$b48
000179556 7001_ $$aOlshan, Andrew F$$b49
000179556 7001_ $$aTroester, Melissa A$$b50
000179556 7001_ $$aHunter, David J$$b51
000179556 7001_ $$aEliassen, Heather A$$b52
000179556 7001_ $$aTamimi, Rulla M$$b53
000179556 7001_ $$aBrantley, Kristen$$b54
000179556 7001_ $$aAndrulis, Irene L$$b55
000179556 7001_ $$aFigueroa, Jonine$$b56
000179556 7001_ $$aChanock, Stephen J$$b57
000179556 7001_ $$aAhearn, Thomas U$$b58
000179556 7001_ $$aGarcía-Closas, Montserrat$$b59
000179556 7001_ $$aEvans, Gareth D$$b60
000179556 7001_ $$aNewman, William G$$b61
000179556 7001_ $$avan Veen, Elke M$$b62
000179556 7001_ $$aHowell, Anthony$$b63
000179556 7001_ $$aWolk, Alicja$$b64
000179556 7001_ $$aHåkansson, Niclas$$b65
000179556 7001_ $$aAnton-Culver, Hoda$$b66
000179556 7001_ $$aZiogas, Argyrios$$b67
000179556 7001_ $$aJones, Michael E$$b68
000179556 7001_ $$aOrr, Nick$$b69
000179556 7001_ $$aSchoemaker, Minouk J$$b70
000179556 7001_ $$aSwerdlow, Anthony J$$b71
000179556 7001_ $$aKitahara, Cari M$$b72
000179556 7001_ $$aLinet, Martha$$b73
000179556 7001_ $$aPrentice, Ross L$$b74
000179556 7001_ $$aEaston, Douglas F$$b75
000179556 7001_ $$aMilne, Roger L$$b76
000179556 7001_ $$aKraft, Peter$$b77
000179556 7001_ $$0P:(DE-He78)c259d6cc99edf5c7bc7ce22c7f87c253$$aChang-Claude, Jenny$$b78$$udkfz
000179556 7001_ $$aLindström, Sara$$b79
000179556 773__ $$0PERI:(DE-600)2615211-3$$a10.1038/s41598-022-10121-2$$gVol. 12, no. 1, p. 6199$$n1$$p6199$$tScientific reports$$v12$$x2045-2322$$y2022
000179556 909CO $$ooai:inrepo02.dkfz.de:179556$$pVDB
000179556 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-HGF)0$$aDeutsches Krebsforschungszentrum$$b1$$kDKFZ
000179556 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)4b2dc91c9d1ac33a1c0e0777d0c1697a$$aDeutsches Krebsforschungszentrum$$b20$$kDKFZ
000179556 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)537e07b3e57b16c7b214fc2242e4326b$$aDeutsches Krebsforschungszentrum$$b24$$kDKFZ
000179556 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)bce1fdec5ce564e2666156d96aeabec9$$aDeutsches Krebsforschungszentrum$$b29$$kDKFZ
000179556 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)c259d6cc99edf5c7bc7ce22c7f87c253$$aDeutsches Krebsforschungszentrum$$b78$$kDKFZ
000179556 9131_ $$0G:(DE-HGF)POF4-313$$1G:(DE-HGF)POF4-310$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lKrebsforschung$$vKrebsrisikofaktoren und Prävention$$x0
000179556 9141_ $$y2022
000179556 915__ $$0LIC:(DE-HGF)CCBYNV$$2V:(DE-HGF)$$aCreative Commons Attribution CC BY (No Version)$$bDOAJ$$d2021-02-03
000179556 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2021-02-03
000179556 915__ $$0StatID:(DE-HGF)1190$$2StatID$$aDBCoverage$$bBiological Abstracts$$d2021-02-03
000179556 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2021-02-03
000179556 915__ $$0StatID:(DE-HGF)0561$$2StatID$$aArticle Processing Charges$$d2021-02-03
000179556 915__ $$0StatID:(DE-HGF)0700$$2StatID$$aFees$$d2021-02-03
000179556 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2022-11-09
000179556 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2022-11-09
000179556 915__ $$0StatID:(DE-HGF)0501$$2StatID$$aDBCoverage$$bDOAJ Seal$$d2022-08-08T09:38:07Z
000179556 915__ $$0StatID:(DE-HGF)0500$$2StatID$$aDBCoverage$$bDOAJ$$d2022-08-08T09:38:07Z
000179556 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bDOAJ : Blind peer review$$d2022-08-08T09:38:07Z
000179556 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search$$d2022-11-09
000179556 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC$$d2022-11-09
000179556 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2022-11-09
000179556 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2022-11-09
000179556 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2022-11-09
000179556 915__ $$0StatID:(DE-HGF)1040$$2StatID$$aDBCoverage$$bZoological Record$$d2022-11-09
000179556 915__ $$0StatID:(DE-HGF)1150$$2StatID$$aDBCoverage$$bCurrent Contents - Physical, Chemical and Earth Sciences$$d2022-11-09
000179556 9201_ $$0I:(DE-He78)C020-20160331$$kC020$$lC020 Epidemiologie von Krebs$$x0
000179556 9201_ $$0I:(DE-He78)B072-20160331$$kB072$$lMolekulargenetik des Mammakarzinoms$$x1
000179556 9201_ $$0I:(DE-He78)B070-20160331$$kB070$$lB070 Funktionelle Genomanalyse$$x2
000179556 980__ $$ajournal
000179556 980__ $$aVDB
000179556 980__ $$aI:(DE-He78)C020-20160331
000179556 980__ $$aI:(DE-He78)B072-20160331
000179556 980__ $$aI:(DE-He78)B070-20160331
000179556 980__ $$aUNRESTRICTED