%0 Journal Article
%A Kliemann, Nathalie
%A Ould Ammar, Romain
%A Biessy, Carine
%A Gicquiau, Audrey
%A Katzke, Verena
%A Kaaks, Rudolf
%A Tjoenneland, Anne
%A Olsen, Anja
%A Sánchez, Maria-Jose
%A Crous-Bou, Marta
%A Pasanisi, Fabrizio
%A Tin Tin, Sandar
%A Perez-Cornago, Aurora
%A Aune, Dagfinn
%A Christakoudi, Sofia
%A Heath, Alicia K
%A Colorado-Yohar, Sandra M
%A Grioni, Sara
%A Skeie, Guri
%A Sartor, Hanna
%A Idahl, Annika
%A Rylander, Charlotta
%A M May, Anne
%A Weiderpass, Elisabete
%A Freisling, Heinz
%A Playdon, Mary C
%A Rinaldi, Sabina
%A Murphy, Neil
%A Huybrechts, Inge
%A Dossus, Laure
%A Gunter, Marc J
%T Metabolically-Defined Body Size Phenotypes and Risk of Endometrial Cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC).
%J Cancer epidemiology, biomarkers & prevention
%V 31
%N 7
%@ 1055-9965
%C Philadelphia, Pa.
%I AACR
%M DKFZ-2022-00765
%P 1359-1367
%D 2022
%Z 2022 Jul 1;31(7):1359-1367
%X Obesity is a risk factor for endometrial cancer but whether metabolic dysfunction is associated with endometrial cancer independent of body size is not known.The association of metabolically-defined body size phenotypes with endometrial cancer risk was investigated in a nested case-control study (817 cases/ 817 controls) within the European Prospective Investigation into Cancer and Nutrition (EPIC). Concentrations of C-peptide were used to define metabolically healthy (MH; <1st tertile) and metabolically unhealthy (MU; >=1st tertile) status among the control participants. These metabolic health definitions were combined with normal weight (NW; Body Mass Index (BMI)<25kg/m2 or Waist Circumference (WC)<80cm or Waist-to-Hip Ratio (WHR)<0.8) and overweight (OW; BMI>=25kg/m2 or WC>=80cm or WHR>=0.8) status, generating four phenotype groups for each anthropometric measure: (1)MH/NW, (2)MH/OW (3)MU/NW and (4)MU/OW.In a multivariable-adjusted conditional logistic regression model, compared with MH/NW individuals, endometrial cancer risk was higher among those classified as MU/NW (OR/WC=1.48; 95
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:35437568
%R 10.1158/1055-9965.EPI-22-0160
%U https://inrepo02.dkfz.de/record/179587