TY  - JOUR
AU  - Kliemann, Nathalie
AU  - Ould Ammar, Romain
AU  - Biessy, Carine
AU  - Gicquiau, Audrey
AU  - Katzke, Verena
AU  - Kaaks, Rudolf
AU  - Tjoenneland, Anne
AU  - Olsen, Anja
AU  - Sánchez, Maria-Jose
AU  - Crous-Bou, Marta
AU  - Pasanisi, Fabrizio
AU  - Tin Tin, Sandar
AU  - Perez-Cornago, Aurora
AU  - Aune, Dagfinn
AU  - Christakoudi, Sofia
AU  - Heath, Alicia K
AU  - Colorado-Yohar, Sandra M
AU  - Grioni, Sara
AU  - Skeie, Guri
AU  - Sartor, Hanna
AU  - Idahl, Annika
AU  - Rylander, Charlotta
AU  - M May, Anne
AU  - Weiderpass, Elisabete
AU  - Freisling, Heinz
AU  - Playdon, Mary C
AU  - Rinaldi, Sabina
AU  - Murphy, Neil
AU  - Huybrechts, Inge
AU  - Dossus, Laure
AU  - Gunter, Marc J
TI  - Metabolically-Defined Body Size Phenotypes and Risk of Endometrial Cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC).
JO  - Cancer epidemiology, biomarkers & prevention
VL  - 31
IS  - 7
SN  - 1055-9965
CY  - Philadelphia, Pa.
PB  - AACR
M1  - DKFZ-2022-00765
SP  - 1359-1367
PY  - 2022
N1  - 2022 Jul 1;31(7):1359-1367
AB  - Obesity is a risk factor for endometrial cancer but whether metabolic dysfunction is associated with endometrial cancer independent of body size is not known.The association of metabolically-defined body size phenotypes with endometrial cancer risk was investigated in a nested case-control study (817 cases/ 817 controls) within the European Prospective Investigation into Cancer and Nutrition (EPIC). Concentrations of C-peptide were used to define metabolically healthy (MH; <1st tertile) and metabolically unhealthy (MU; >=1st tertile) status among the control participants. These metabolic health definitions were combined with normal weight (NW; Body Mass Index (BMI)<25kg/m2 or Waist Circumference (WC)<80cm or Waist-to-Hip Ratio (WHR)<0.8) and overweight (OW; BMI>=25kg/m2 or WC>=80cm or WHR>=0.8) status, generating four phenotype groups for each anthropometric measure: (1)MH/NW, (2)MH/OW (3)MU/NW and (4)MU/OW.In a multivariable-adjusted conditional logistic regression model, compared with MH/NW individuals, endometrial cancer risk was higher among those classified as MU/NW (OR/WC=1.48; 95
LB  - PUB:(DE-HGF)16
C6  - pmid:35437568
DO  - DOI:10.1158/1055-9965.EPI-22-0160
UR  - https://inrepo02.dkfz.de/record/179587
ER  -