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000179588 037__ $$aDKFZ-2022-00766
000179588 041__ $$aEnglish
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000179588 1001_ $$aCairat, Manon$$b0
000179588 245__ $$aCirculating inflammatory biomarkers, adipokines and breast cancer risk-a case-control study nested within the EPIC cohort.
000179588 260__ $$aHeidelberg [u.a.]$$bSpringer$$c2022
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000179588 520__ $$aInflammation has been hypothesized to play a role in the development and progression of breast cancer and might differently impact breast cancer risk among pre and postmenopausal women. We performed a nested case-control study to examine whether pre-diagnostic circulating concentrations of adiponectin, leptin, c-reactive protein (CRP), tumour necrosis factor-α, interferon-γ and 6 interleukins were associated with breast cancer risk, overall and by menopausal status.Pre-diagnostic levels of inflammatory biomarkers were measured in plasma from 1558 case-control pairs from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. We used conditional logistic regression to estimate the odds ratios (ORs) of breast cancer at blood collection, per one standard deviation increase in biomarker concentration.Cases were diagnosed at a mean age of 61.4 years on average 8.6 years after blood collection. No statistically significant association was observed between inflammatory markers and breast cancer risk overall. In premenopausal women, borderline significant inverse associations were observed for leptin, leptin-to-adiponectin ratio and CRP [OR= 0.89 (0.77-1.03), OR= 0.88 (0.76-1.01) and OR= 0.87 (0.75-1.01), respectively] while positive associations were observed among postmenopausal women [OR= 1.16 (1.05-1.29), OR= 1.11 (1.01-1.23), OR= 1.10 (0.99-1.22), respectively]. Adjustment for BMI strengthened the estimates in premenopausal women [leptin: OR = 0.83 (0.68-1.00), leptin-to-adiponectin ratio: OR = 0.80 (0.66-0.97), CRP: OR = 0.85 (0.72-1.00)] but attenuated the estimates in postmenopausal women [leptin: OR = 1.09 (0.96-1.24), leptin-to-adiponectin ratio: OR = 1.02 (0.89-1.16), CRP: OR = 1.04 (0.92-1.16)].Associations between CRP, leptin and leptin-to-adiponectin ratio with breast cancer risk may represent the dual effect of obesity by menopausal status although this deserves further investigation.
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000179588 650_7 $$2Other$$aAnthropometry
000179588 650_7 $$2Other$$aBiomarkers
000179588 650_7 $$2Other$$aBreast cancer
000179588 650_7 $$2Other$$aInflammation
000179588 650_7 $$2Other$$aMenopausal status
000179588 650_7 $$2NLM Chemicals$$aAdipokines
000179588 650_7 $$2NLM Chemicals$$aAdiponectin
000179588 650_7 $$2NLM Chemicals$$aBiomarkers
000179588 650_7 $$2NLM Chemicals$$aLeptin
000179588 650_7 $$09007-41-4$$2NLM Chemicals$$aC-Reactive Protein
000179588 650_2 $$2MeSH$$aAdipokines
000179588 650_2 $$2MeSH$$aAdiponectin
000179588 650_2 $$2MeSH$$aBiomarkers
000179588 650_2 $$2MeSH$$aBody Mass Index
000179588 650_2 $$2MeSH$$aBreast Neoplasms: diagnosis
000179588 650_2 $$2MeSH$$aBreast Neoplasms: epidemiology
000179588 650_2 $$2MeSH$$aC-Reactive Protein: metabolism
000179588 650_2 $$2MeSH$$aCase-Control Studies
000179588 650_2 $$2MeSH$$aFemale
000179588 650_2 $$2MeSH$$aHumans
000179588 650_2 $$2MeSH$$aLeptin
000179588 650_2 $$2MeSH$$aMiddle Aged
000179588 650_2 $$2MeSH$$aProspective Studies
000179588 650_2 $$2MeSH$$aRisk Factors
000179588 7001_ $$aRinaldi, Sabina$$b1
000179588 7001_ $$aNavionis, Anne-Sophie$$b2
000179588 7001_ $$aRomieu, Isabelle$$b3
000179588 7001_ $$aBiessy, Carine$$b4
000179588 7001_ $$aViallon, Vivian$$b5
000179588 7001_ $$aOlsen, Anja$$b6
000179588 7001_ $$aTjønneland, Anne$$b7
000179588 7001_ $$aFournier, Agnès$$b8
000179588 7001_ $$aSeveri, Gianluca$$b9
000179588 7001_ $$aKvaskoff, Marina$$b10
000179588 7001_ $$0P:(DE-He78)74a6af8347ec5cbd4b77e562e10ca1f2$$aFortner, Renée T$$b11$$udkfz
000179588 7001_ $$0P:(DE-He78)4b2dc91c9d1ac33a1c0e0777d0c1697a$$aKaaks, Rudolf$$b12$$udkfz
000179588 7001_ $$aAleksandrova, Krasimira$$b13
000179588 7001_ $$aSchulze, Matthias B$$b14
000179588 7001_ $$aMasala, Giovanna$$b15
000179588 7001_ $$aTumino, Rosario$$b16
000179588 7001_ $$aSieri, Sabina$$b17
000179588 7001_ $$aGrasso, Chiara$$b18
000179588 7001_ $$aMattiello, Amalia$$b19
000179588 7001_ $$aGram, Inger T$$b20
000179588 7001_ $$aOlsen, Karina Standahl$$b21
000179588 7001_ $$aAgudo, Antonio$$b22
000179588 7001_ $$aEtxezarreta, Pilar Amiano$$b23
000179588 7001_ $$aSánchez, Maria-Jose$$b24
000179588 7001_ $$aSantiuste, Carmen$$b25
000179588 7001_ $$aBarricarte, Aurelio$$b26
000179588 7001_ $$aMonninkhof, Evelyn$$b27
000179588 7001_ $$aHiensch, Anouk E$$b28
000179588 7001_ $$aMuller, David$$b29
000179588 7001_ $$aMerritt, Melissa A$$b30
000179588 7001_ $$aTravis, Ruth C$$b31
000179588 7001_ $$aWeiderpass, Elisabete$$b32
000179588 7001_ $$aGunter, Marc J$$b33
000179588 7001_ $$00000-0003-2716-5748$$aDossus, Laure$$b34
000179588 773__ $$0PERI:(DE-600)2131669-7$$a10.1186/s12916-022-02319-y$$gVol. 20, no. 1, p. 118$$n1$$p118$$tBMC medicine$$v20$$x1741-7015$$y2022
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