TY  - JOUR
AU  - Cairat, Manon
AU  - Rinaldi, Sabina
AU  - Navionis, Anne-Sophie
AU  - Romieu, Isabelle
AU  - Biessy, Carine
AU  - Viallon, Vivian
AU  - Olsen, Anja
AU  - Tjønneland, Anne
AU  - Fournier, Agnès
AU  - Severi, Gianluca
AU  - Kvaskoff, Marina
AU  - Fortner, Renée T
AU  - Kaaks, Rudolf
AU  - Aleksandrova, Krasimira
AU  - Schulze, Matthias B
AU  - Masala, Giovanna
AU  - Tumino, Rosario
AU  - Sieri, Sabina
AU  - Grasso, Chiara
AU  - Mattiello, Amalia
AU  - Gram, Inger T
AU  - Olsen, Karina Standahl
AU  - Agudo, Antonio
AU  - Etxezarreta, Pilar Amiano
AU  - Sánchez, Maria-Jose
AU  - Santiuste, Carmen
AU  - Barricarte, Aurelio
AU  - Monninkhof, Evelyn
AU  - Hiensch, Anouk E
AU  - Muller, David
AU  - Merritt, Melissa A
AU  - Travis, Ruth C
AU  - Weiderpass, Elisabete
AU  - Gunter, Marc J
AU  - Dossus, Laure
TI  - Circulating inflammatory biomarkers, adipokines and breast cancer risk-a case-control study nested within the EPIC cohort.
JO  - BMC medicine
VL  - 20
IS  - 1
SN  - 1741-7015
CY  - Heidelberg [u.a.]
PB  - Springer
M1  - DKFZ-2022-00766
SP  - 118
PY  - 2022
AB  - Inflammation has been hypothesized to play a role in the development and progression of breast cancer and might differently impact breast cancer risk among pre and postmenopausal women. We performed a nested case-control study to examine whether pre-diagnostic circulating concentrations of adiponectin, leptin, c-reactive protein (CRP), tumour necrosis factor-α, interferon-γ and 6 interleukins were associated with breast cancer risk, overall and by menopausal status.Pre-diagnostic levels of inflammatory biomarkers were measured in plasma from 1558 case-control pairs from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. We used conditional logistic regression to estimate the odds ratios (ORs) of breast cancer at blood collection, per one standard deviation increase in biomarker concentration.Cases were diagnosed at a mean age of 61.4 years on average 8.6 years after blood collection. No statistically significant association was observed between inflammatory markers and breast cancer risk overall. In premenopausal women, borderline significant inverse associations were observed for leptin, leptin-to-adiponectin ratio and CRP [OR= 0.89 (0.77-1.03), OR= 0.88 (0.76-1.01) and OR= 0.87 (0.75-1.01), respectively] while positive associations were observed among postmenopausal women [OR= 1.16 (1.05-1.29), OR= 1.11 (1.01-1.23), OR= 1.10 (0.99-1.22), respectively]. Adjustment for BMI strengthened the estimates in premenopausal women [leptin: OR = 0.83 (0.68-1.00), leptin-to-adiponectin ratio: OR = 0.80 (0.66-0.97), CRP: OR = 0.85 (0.72-1.00)] but attenuated the estimates in postmenopausal women [leptin: OR = 1.09 (0.96-1.24), leptin-to-adiponectin ratio: OR = 1.02 (0.89-1.16), CRP: OR = 1.04 (0.92-1.16)].Associations between CRP, leptin and leptin-to-adiponectin ratio with breast cancer risk may represent the dual effect of obesity by menopausal status although this deserves further investigation.
KW  - Adipokines
KW  - Adiponectin
KW  - Biomarkers
KW  - Body Mass Index
KW  - Breast Neoplasms: diagnosis
KW  - Breast Neoplasms: epidemiology
KW  - C-Reactive Protein: metabolism
KW  - Case-Control Studies
KW  - Female
KW  - Humans
KW  - Leptin
KW  - Middle Aged
KW  - Prospective Studies
KW  - Risk Factors
KW  - Anthropometry (Other)
KW  - Biomarkers (Other)
KW  - Breast cancer (Other)
KW  - Inflammation (Other)
KW  - Menopausal status (Other)
KW  - Adipokines (NLM Chemicals)
KW  - Adiponectin (NLM Chemicals)
KW  - Biomarkers (NLM Chemicals)
KW  - Leptin (NLM Chemicals)
KW  - C-Reactive Protein (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:35430795
C2  - pmc:PMC9014562
DO  - DOI:10.1186/s12916-022-02319-y
UR  - https://inrepo02.dkfz.de/record/179588
ER  -