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@ARTICLE{Ferrari:179755,
      author       = {A. Ferrari and D. Orbach and M. Sparber-Sauer and D. O.
                      Walterhouse and K. W. Pajtler$^*$ and W. H. Meyer and S. L.
                      Spunt and A. R. Weiss},
      title        = {{T}he treatment approach to pediatric non-rhabdomyosarcoma
                      soft tissue sarcomas: a critical review from the
                      {IN}ternational {S}oft {T}issue {S}a{R}coma {C}onsor{T}ium.},
      journal      = {European journal of cancer},
      volume       = {169},
      issn         = {0014-2964},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier},
      reportid     = {DKFZ-2022-00882},
      pages        = {10 - 19},
      year         = {2022},
      abstract     = {The current article focuses on non-rhabdomyosarcoma soft
                      tissue sarcoma (NRSTS), the heterogeneous group of
                      mesenchymal tumours different from rhabdomyosarcoma that may
                      affect children and adolescents, with clinical behaviour
                      varying from relatively benign to highly malignant. This
                      review represents the effort of the international scientific
                      paediatric community within the context of the INternational
                      Soft Tissue SaRcoma ConsorTium (INSTRuCT), a project founded
                      by the leadership of three large cooperative groups -
                      Children's Oncology Group, Cooperative Weichteilsarkom
                      Studiengruppe and European paediatric Soft tissue sarcoma
                      Study Group - with the main goal to pool expertise and
                      resources on a broader international level in order to
                      improve knowledge of soft tissue sarcomas of children,
                      adolescents and young adults. This article describes the
                      current standard treatment approach in NRSTS, with a focus
                      on the controversies and challenges in the management of
                      these tumours. Developing research projects and clinical
                      protocols for NRSTS has always been challenging, supporting
                      the need to develop international integrated prospective
                      dedicated programs, including paediatric NRSTS experts
                      together with the adult sarcoma community. INSTRuCT provides
                      a unique mechanism to increase international collaboration
                      by agreeing on a common language, developing consensus
                      standards to guide diagnosis and treatment, comparing
                      clinical trial results across cooperative groups, and
                      through a shared data dictionary providing answers to
                      questions that can only be addressed by a larger data set.},
      subtyp        = {Review Article},
      keywords     = {INSTRuCT (Other) / NRSTS (Other) / Non-rhabdomyosarcoma
                      soft tissue sarcomas (Other) / Review (Other) / Standard
                      (Other) / Treatment (Other)},
      cin          = {B062 / HD01},
      ddc          = {610},
      cid          = {I:(DE-He78)B062-20160331 / I:(DE-He78)HD01-20160331},
      pnm          = {312 - Funktionelle und strukturelle Genomforschung
                      (POF4-312)},
      pid          = {G:(DE-HGF)POF4-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:35490564},
      doi          = {10.1016/j.ejca.2022.03.028},
      url          = {https://inrepo02.dkfz.de/record/179755},
}