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@ARTICLE{Ferrari:179755,
author = {A. Ferrari and D. Orbach and M. Sparber-Sauer and D. O.
Walterhouse and K. W. Pajtler$^*$ and W. H. Meyer and S. L.
Spunt and A. R. Weiss},
title = {{T}he treatment approach to pediatric non-rhabdomyosarcoma
soft tissue sarcomas: a critical review from the
{IN}ternational {S}oft {T}issue {S}a{R}coma {C}onsor{T}ium.},
journal = {European journal of cancer},
volume = {169},
issn = {0014-2964},
address = {Amsterdam [u.a.]},
publisher = {Elsevier},
reportid = {DKFZ-2022-00882},
pages = {10 - 19},
year = {2022},
abstract = {The current article focuses on non-rhabdomyosarcoma soft
tissue sarcoma (NRSTS), the heterogeneous group of
mesenchymal tumours different from rhabdomyosarcoma that may
affect children and adolescents, with clinical behaviour
varying from relatively benign to highly malignant. This
review represents the effort of the international scientific
paediatric community within the context of the INternational
Soft Tissue SaRcoma ConsorTium (INSTRuCT), a project founded
by the leadership of three large cooperative groups -
Children's Oncology Group, Cooperative Weichteilsarkom
Studiengruppe and European paediatric Soft tissue sarcoma
Study Group - with the main goal to pool expertise and
resources on a broader international level in order to
improve knowledge of soft tissue sarcomas of children,
adolescents and young adults. This article describes the
current standard treatment approach in NRSTS, with a focus
on the controversies and challenges in the management of
these tumours. Developing research projects and clinical
protocols for NRSTS has always been challenging, supporting
the need to develop international integrated prospective
dedicated programs, including paediatric NRSTS experts
together with the adult sarcoma community. INSTRuCT provides
a unique mechanism to increase international collaboration
by agreeing on a common language, developing consensus
standards to guide diagnosis and treatment, comparing
clinical trial results across cooperative groups, and
through a shared data dictionary providing answers to
questions that can only be addressed by a larger data set.},
subtyp = {Review Article},
keywords = {INSTRuCT (Other) / NRSTS (Other) / Non-rhabdomyosarcoma
soft tissue sarcomas (Other) / Review (Other) / Standard
(Other) / Treatment (Other)},
cin = {B062 / HD01},
ddc = {610},
cid = {I:(DE-He78)B062-20160331 / I:(DE-He78)HD01-20160331},
pnm = {312 - Funktionelle und strukturelle Genomforschung
(POF4-312)},
pid = {G:(DE-HGF)POF4-312},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:35490564},
doi = {10.1016/j.ejca.2022.03.028},
url = {https://inrepo02.dkfz.de/record/179755},
}