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@ARTICLE{Chen:179882,
      author       = {L.-J. Chen$^*$ and T. N. M. Nguyen$^*$ and J.
                      Chang-Claude$^*$ and M. Hoffmeister$^*$ and H. Brenner$^*$
                      and B. Schöttker$^*$},
      title        = {{I}ncorporation of functional status, frailty,
                      comorbidities and comedication in prediction models for
                      colorectal cancer survival.},
      journal      = {International journal of cancer},
      volume       = {151},
      number       = {4},
      issn         = {0020-7136},
      address      = {Bognor Regis},
      publisher    = {Wiley-Liss},
      reportid     = {DKFZ-2022-00944},
      pages        = {539-552},
      year         = {2022},
      note         = {#EA:C070#LA:C070# / 2022 Aug 15;151(4):539-552},
      abstract     = {Limitations in functional status, frailty, multiple
                      comorbidities and comedications are common among older
                      colorectal cancer (CRC) patients. We investigated whether
                      adding these factors could improve the predictive value of a
                      reference model containing age, sex, tumor stage and
                      location for prediction of 5-year overall survival (OS),
                      disease-free survival (DFS), disease-specific survival
                      (DSS), recurrence-free survival (RFS) and
                      nondisease-specific survival (nDSS) for all CRC patients as
                      well as for younger (<65 years) and older patients (≥65
                      years). Overall, 3410 CRC patients from the DACHS study were
                      analyzed and area under receiver operating characteristic
                      curves (AUC) and net reclassification improvements (NRI)
                      were assessed. In prediction of OS, the reference model plus
                      functional status was identified as the best model among all
                      CRC patients (AUC: 0.762) and younger CRC patients (AUC:
                      0.820). In older CRC patients, comorbidity should
                      additionally be added (AUC: 0.747). For nDSS, the reference
                      model plus comorbidity and frailty had the best predictive
                      performance in all CRC patients (AUC: 0.776). For the
                      outcomes DFS (AUC: 0.727), DSS (AUC: 0.838) and RFS (AUC:
                      0.784), the reference model was already the best model in
                      all CRC patients because no significant NRIs were observed.
                      The pattern 'The less CRC-specific the survival outcome and
                      the older the CRC patients, the more relevant the inclusion
                      of functional status, comorbidity, and frailty in CRC
                      prognostic scores is' was observed. Thus, different
                      nomograms for younger and older CRC patients for 1-, 3- and
                      5-year OS prognosis estimation are being suggested.},
      keywords     = {colorectal cancer prognosis (Other) / comedication (Other)
                      / comorbidity (Other) / frailty (Other) / functional status
                      (Other)},
      cin          = {C070 / C020 / C120 / HD01},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331 / I:(DE-He78)C020-20160331 /
                      I:(DE-He78)C120-20160331 / I:(DE-He78)HD01-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:35435251},
      doi          = {10.1002/ijc.34036},
      url          = {https://inrepo02.dkfz.de/record/179882},
}