guest ::
| Home > Publications database > A synergistic interaction between HDAC- and PARP inhibitors in childhood tumors with chromothripsis. > print |
| Home > Publications database > A synergistic interaction between HDAC- and PARP inhibitors in childhood tumors with chromothripsis. > print |
| 001 | 179901 | ||
| 005 | 20241219120840.0 | ||
| 024 | 7 | _ | |a 10.1002/ijc.34027 |2 doi |
| 024 | 7 | _ | |a pmid:35411591 |2 pmid |
| 024 | 7 | _ | |a 0020-7136 |2 ISSN |
| 024 | 7 | _ | |a 1097-0215 |2 ISSN |
| 024 | 7 | _ | |a altmetric:126482420 |2 altmetric |
| 037 | _ | _ | |a DKFZ-2022-00958 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Khalid, Umar |0 P:(DE-He78)794761a765ceca759536a1bf39100142 |b 0 |e First author |u dkfz |
| 245 | _ | _ | |a A synergistic interaction between HDAC- and PARP inhibitors in childhood tumors with chromothripsis. |
| 260 | _ | _ | |a Bognor Regis |c 2022 |b Wiley-Liss |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1656680403_3318 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 500 | _ | _ | |a #EA:B420#LA:B420# / 2022 Aug 15;151(4):590-606 |
| 520 | _ | _ | |a Chromothripsis is a form of genomic instability characterized by the occurrence of tens to hundreds of clustered DNA double-strand breaks in a one-off catastrophic event. Rearrangements associated with chromothripsis are detectable in numerous tumor entities and linked with poor prognosis in some of these, such as Sonic Hedgehog medulloblastoma, neuroblastoma and osteosarcoma. Hence, there is a need for therapeutic strategies eliminating tumor cells with chromothripsis. Defects in DNA double-strand break repair, and in particular homologous recombination repair, have been linked with chromothripsis. Targeting DNA repair deficiencies by synthetic lethality approaches, we performed a synergy screen using drug libraries (n = 375 compounds, 15 models) combined with either a PARP inhibitor or cisplatin. This revealed a synergistic interaction between the HDAC inhibitor romidepsin and PARP inhibition. Functional assays, transcriptome analyses and in vivo validation in patient-derived xenograft mouse models confirmed the efficacy of the combinatorial treatment. |
| 536 | _ | _ | |a 312 - Funktionelle und strukturelle Genomforschung (POF4-312) |0 G:(DE-HGF)POF4-312 |c POF4-312 |f POF IV |x 0 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, , Journals: inrepo02.dkfz.de |
| 650 | _ | 7 | |a HDAC inhibitor |2 Other |
| 650 | _ | 7 | |a PARP inhibitor |2 Other |
| 650 | _ | 7 | |a chromothripsis |2 Other |
| 650 | _ | 7 | |a synergy |2 Other |
| 650 | _ | 7 | |a synthetic lethality |2 Other |
| 700 | 1 | _ | |a Simovic, Milena |0 P:(DE-He78)1fdaffee272e57a73f861a0ea36c4079 |b 1 |u dkfz |
| 700 | 1 | _ | |a Hammann, Linda A |0 P:(DE-He78)6268906e54e5ca1f69e966a42d92bff7 |b 2 |u dkfz |
| 700 | 1 | _ | |a Iskar, Murat |0 P:(DE-He78)f28fcc92d5c00f3ee511e3319c699b38 |b 3 |u dkfz |
| 700 | 1 | _ | |a Wong, John K L |0 P:(DE-HGF)0 |b 4 |
| 700 | 1 | _ | |a Kumar, Rithu |0 P:(DE-He78)c5cc0ee57f0d49302de5365f8cb9206e |b 5 |u dkfz |
| 700 | 1 | _ | |a Jugold, Manfred |0 P:(DE-He78)f12dec7b80065347181cf69f8233b40d |b 6 |u dkfz |
| 700 | 1 | _ | |a Sill, Martin |0 P:(DE-He78)45440b44791309bd4b7dbb4f73333f9b |b 7 |u dkfz |
| 700 | 1 | _ | |a Bolkestein, Michiel |0 P:(DE-He78)2f672b5ff4fc0d5ba62362e2be763b33 |b 8 |
| 700 | 1 | _ | |a Kolb, Thorsten |0 P:(DE-He78)ff4b82323a90d759d3c7eef0fd8ddfe3 |b 9 |u dkfz |
| 700 | 1 | _ | |a Hergt, Michaela |0 P:(DE-He78)0a9866797138423749f3c3b00d53e1cc |b 10 |u dkfz |
| 700 | 1 | _ | |a Devens, Frauke |0 P:(DE-He78)83cd6bd6ea17b47e625c371d6415bdea |b 11 |u dkfz |
| 700 | 1 | _ | |a Ecker, Jonas |0 P:(DE-He78)3de637452ba900e2bdd359b8f41953bf |b 12 |u dkfz |
| 700 | 1 | _ | |a Kool, Marcel |0 P:(DE-He78)4c28e2aade5f44d8eca9dd8e97638ec8 |b 13 |u dkfz |
| 700 | 1 | _ | |a Milde, Till |0 P:(DE-He78)0be2f86573954f87e97f8a4dbb05cb0f |b 14 |u dkfz |
| 700 | 1 | _ | |a Westermann, Frank |0 P:(DE-He78)91f32735ee876c579d63c05a7f4778dd |b 15 |u dkfz |
| 700 | 1 | _ | |a Benner, Axel |0 P:(DE-He78)e15dfa1260625c69d6690a197392a994 |b 16 |u dkfz |
| 700 | 1 | _ | |a Lewis, Joe |b 17 |
| 700 | 1 | _ | |a Dietrich, Sascha |b 18 |
| 700 | 1 | _ | |a Pfister, Stefan M |0 P:(DE-He78)f746aa965c4e1af518b016de3aaff5d9 |b 19 |u dkfz |
| 700 | 1 | _ | |a Lichter, Peter |0 P:(DE-He78)e13b4363c5fe858044ef8a39c02c870c |b 20 |u dkfz |
| 700 | 1 | _ | |a Zapatka, Marc |0 P:(DE-He78)1beba8f953e7ae7e96e8d3e9a48f10f7 |b 21 |u dkfz |
| 700 | 1 | _ | |a Ernst, Aurélie |0 P:(DE-He78)509fb81813c1911954da583129e8ea57 |b 22 |e Last author |u dkfz |
| 773 | _ | _ | |a 10.1002/ijc.34027 |g p. ijc.34027 |0 PERI:(DE-600)1474822-8 |n 4 |p 590-606 |t International journal of cancer |v 151 |y 2022 |x 0020-7136 |
| 909 | C | O | |o oai:inrepo02.dkfz.de:179901 |p VDB |p OpenAPC |p openCost |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 0 |6 P:(DE-He78)794761a765ceca759536a1bf39100142 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 1 |6 P:(DE-He78)1fdaffee272e57a73f861a0ea36c4079 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 2 |6 P:(DE-He78)6268906e54e5ca1f69e966a42d92bff7 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 3 |6 P:(DE-He78)f28fcc92d5c00f3ee511e3319c699b38 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 4 |6 P:(DE-HGF)0 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 5 |6 P:(DE-He78)c5cc0ee57f0d49302de5365f8cb9206e |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 6 |6 P:(DE-He78)f12dec7b80065347181cf69f8233b40d |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 7 |6 P:(DE-He78)45440b44791309bd4b7dbb4f73333f9b |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 8 |6 P:(DE-He78)2f672b5ff4fc0d5ba62362e2be763b33 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 9 |6 P:(DE-He78)ff4b82323a90d759d3c7eef0fd8ddfe3 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 10 |6 P:(DE-He78)0a9866797138423749f3c3b00d53e1cc |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 11 |6 P:(DE-He78)83cd6bd6ea17b47e625c371d6415bdea |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 12 |6 P:(DE-He78)3de637452ba900e2bdd359b8f41953bf |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 13 |6 P:(DE-He78)4c28e2aade5f44d8eca9dd8e97638ec8 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 14 |6 P:(DE-He78)0be2f86573954f87e97f8a4dbb05cb0f |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 15 |6 P:(DE-He78)91f32735ee876c579d63c05a7f4778dd |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 16 |6 P:(DE-He78)e15dfa1260625c69d6690a197392a994 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 19 |6 P:(DE-He78)f746aa965c4e1af518b016de3aaff5d9 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 20 |6 P:(DE-He78)e13b4363c5fe858044ef8a39c02c870c |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 21 |6 P:(DE-He78)1beba8f953e7ae7e96e8d3e9a48f10f7 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 22 |6 P:(DE-He78)509fb81813c1911954da583129e8ea57 |
| 913 | 1 | _ | |a DE-HGF |b Gesundheit |l Krebsforschung |1 G:(DE-HGF)POF4-310 |0 G:(DE-HGF)POF4-312 |3 G:(DE-HGF)POF4 |2 G:(DE-HGF)POF4-300 |4 G:(DE-HGF)POF |v Funktionelle und strukturelle Genomforschung |x 0 |
| 914 | 1 | _ | |y 2022 |
| 915 | _ | _ | |a DEAL Wiley |0 StatID:(DE-HGF)3001 |2 StatID |d 2021-02-04 |w ger |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0160 |2 StatID |b Essential Science Indicators |d 2021-02-04 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1190 |2 StatID |b Biological Abstracts |d 2021-02-04 |
| 915 | _ | _ | |a WoS |0 StatID:(DE-HGF)0113 |2 StatID |b Science Citation Index Expanded |d 2021-02-04 |
| 915 | _ | _ | |a Nationallizenz |0 StatID:(DE-HGF)0420 |2 StatID |d 2022-11-25 |w ger |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0200 |2 StatID |b SCOPUS |d 2022-11-25 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0300 |2 StatID |b Medline |d 2022-11-25 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0199 |2 StatID |b Clarivate Analytics Master Journal List |d 2022-11-25 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0150 |2 StatID |b Web of Science Core Collection |d 2022-11-25 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1050 |2 StatID |b BIOSIS Previews |d 2022-11-25 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1030 |2 StatID |b Current Contents - Life Sciences |d 2022-11-25 |
| 915 | _ | _ | |a JCR |0 StatID:(DE-HGF)0100 |2 StatID |b INT J CANCER : 2021 |d 2022-11-25 |
| 915 | _ | _ | |a IF >= 5 |0 StatID:(DE-HGF)9905 |2 StatID |b INT J CANCER : 2021 |d 2022-11-25 |
| 915 | p | c | |a APC keys set |2 APC |0 PC:(DE-HGF)0000 |
| 915 | p | c | |a Local Funding |2 APC |0 PC:(DE-HGF)0001 |
| 920 | 2 | _ | |0 I:(DE-He78)B420-20160331 |k B420 |l Genominstabilität in Tumoren |x 0 |
| 920 | 1 | _ | |0 I:(DE-He78)B420-20160331 |k B420 |l Genominstabilität in Tumoren |x 0 |
| 920 | 1 | _ | |0 I:(DE-He78)B060-20160331 |k B060 |l B060 Molekulare Genetik |x 1 |
| 920 | 1 | _ | |0 I:(DE-He78)W240-20160331 |k W240 |l Core Facility Kleinbildgebung |x 2 |
| 920 | 1 | _ | |0 I:(DE-He78)B062-20160331 |k B062 |l B062 Pädiatrische Neuroonkologie |x 3 |
| 920 | 1 | _ | |0 I:(DE-He78)HD01-20160331 |k HD01 |l DKTK HD zentral |x 4 |
| 920 | 1 | _ | |0 I:(DE-He78)B310-20160331 |k B310 |l KKE Pädiatrische Onkologie |x 5 |
| 920 | 1 | _ | |0 I:(DE-He78)B087-20160331 |k B087 |l B087 Neuroblastom Genomik |x 6 |
| 920 | 1 | _ | |0 I:(DE-He78)C060-20160331 |k C060 |l C060 Biostatistik |x 7 |
| 920 | 0 | _ | |0 I:(DE-He78)B420-20160331 |k B420 |l Genominstabilität in Tumoren |x 0 |
| 980 | _ | _ | |a journal |
| 980 | _ | _ | |a VDB |
| 980 | _ | _ | |a I:(DE-He78)B420-20160331 |
| 980 | _ | _ | |a I:(DE-He78)B060-20160331 |
| 980 | _ | _ | |a I:(DE-He78)W240-20160331 |
| 980 | _ | _ | |a I:(DE-He78)B062-20160331 |
| 980 | _ | _ | |a I:(DE-He78)HD01-20160331 |
| 980 | _ | _ | |a I:(DE-He78)B310-20160331 |
| 980 | _ | _ | |a I:(DE-He78)B087-20160331 |
| 980 | _ | _ | |a I:(DE-He78)C060-20160331 |
| 980 | _ | _ | |a UNRESTRICTED |
| 980 | _ | _ | |a APC |
| Library | Collection | CLSMajor | CLSMinor | Language | Author |
|---|