TY  - JOUR
AU  - Kohls, Mirjam
AU  - Freisling, Heinz
AU  - Charvat, Hadrien
AU  - Soerjomataram, Isabelle
AU  - Viallon, Vivian
AU  - Davila-Batista, Veronica
AU  - Kaaks, Rudolf
AU  - Turzanski-Fortner, Renée
AU  - Aleksandrova, Krasimira
AU  - Schulze, Matthias B
AU  - Dahm, Christina C
AU  - Tilma Vistisen, Helene
AU  - Rostgaard-Hansen, Agnetha Linn
AU  - Tjønneland, Anne
AU  - Bonet, Catalina
AU  - Sánchez, Maria-Jose
AU  - Colorado-Yohar, Sandra
AU  - Masala, Giovanna
AU  - Palli, Domenico
AU  - Krogh, Vittorio
AU  - Ricceri, Fulvio
AU  - Rolandsson, Olov
AU  - Lu, Sai San Moon
AU  - Tsilidis, Konstantinos K
AU  - Weiderpass, Elisabete
AU  - Gunter, Marc J
AU  - Ferrari, Pietro
AU  - Berger, Ursula
AU  - Arnold, Melina
TI  - Impact of cumulative body mass index and cardiometabolic diseases on survival among patients with colorectal and breast cancer: a multi-centre cohort study.
JO  - BMC cancer
VL  - 22
IS  - 1
SN  - 1471-2407
CY  - Heidelberg
PB  - Springer
M1  - DKFZ-2022-00968
SP  - 546
PY  - 2022
AB  - Body mass index (BMI) and cardiometabolic comorbidities such as cardiovascular disease and type 2 diabetes have been studied as negative prognostic factors in cancer survival, but possible dependencies in the mechanisms underlying these associations remain largely unexplored. We analysed these associations in colorectal and breast cancer patients.Based on repeated BMI assessments of cancer-free participants from four European countries in the European Prospective Investigation into Cancer and nutrition (EPIC) study, individual BMI-trajectories reflecting predicted mean BMI between ages 20 to 50 years were estimated using a growth curve model. Participants with incident colorectal or breast cancer after the age of 50 years were included in the survival analysis to study the prognostic effect of mean BMI and cardiometabolic diseases (CMD) prior to cancer. CMD were defined as one or more chronic conditions among stroke, myocardial infarction, and type 2 diabetes. Hazard ratios (HRs) and confidence intervals (CIs) of mean BMI and CMD were derived using multivariable-adjusted Cox proportional hazard regression for mean BMI and CMD separately and both exposures combined, in subgroups of localised and advanced disease.In the total cohort of 159,045 participants, there were 1,045 and 1,620 eligible patients of colorectal and breast cancer. In colorectal cancer patients, a higher BMI (by 1 kg/m2) was associated with a 6
KW  - Body mass index (Other)
KW  - Breast cancer (Other)
KW  - Cardiovascular disease (Other)
KW  - Cohort study (Other)
KW  - Colorectal cancer (Other)
KW  - Comorbidity (Other)
KW  - Cumulative exposure (Other)
KW  - Diabetes (Other)
KW  - Survival (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:35568802
DO  - DOI:10.1186/s12885-022-09589-y
UR  - https://inrepo02.dkfz.de/record/179919
ER  -