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@ARTICLE{Schott:179952,
      author       = {A. Schott and A. Kluttig and R. Mikolajczyk and K. H.
                      Greiser$^*$ and K. Werdan and D. Sedding and S. Nuding},
      title        = {{A}ssociation of arterial stiffness and heart failure with
                      preserved ejection fraction in the elderly population -
                      results from the {CARLA} study.},
      journal      = {Journal of human hypertension},
      volume       = {37},
      number       = {6},
      issn         = {0950-9240},
      address      = {London, UK},
      publisher    = {Springer Nature},
      reportid     = {DKFZ-2022-01001},
      pages        = {463-471},
      year         = {2023},
      note         = {2023 Jun;37(6):463-471},
      abstract     = {Arterial stiffness has been suspected as a cause of left
                      ventricular diastolic dysfunction and may thereby contribute
                      to the development of heart failure with preserved ejection
                      fraction (HFpEF). However, this association is derived from
                      a small number of studies and application of outdated
                      criteria to diagnose HFpEF. This study aimed to investigate
                      the association of arterial stiffness measured by the
                      augmentation index (AIx) and criteria for diagnosing HFpEF
                      according to the recommended HFA-PEFF score. Our analysis
                      based on data from the first follow-up of the CARdiovascular
                      Disease, Living and Ageing in Halle study. The current
                      analysis included participants with available information
                      about comorbidities and risk factors for HFpEF, parameters
                      for calculation of the HFA-PEFF and noninvasive AIx
                      estimated by applanation tonometry. The association of AIx
                      and HFA-PEFF was investigated through descriptive and
                      inductive statistics. A total of 767 participants were
                      included in the analysis. AIx was associated with E/e', left
                      ventricular wall thickness (LVWT), relative wall thickness,
                      left ventricular mass index (LVMI) and NT-proBNP but not
                      with e' or left atrial volume index. However, after
                      adjustment for confounders, only LVMI and LVWT remained
                      associated with AIx. Males with a high AIx had a 3.2-fold
                      higher likelihood of HFpEF than those with a low AIx. In
                      contrast, that association was not present in females. In
                      summary, AIx is associated with the morphological domain of
                      the HFA-PEFF score represented by LVMI and LVWT. Higher
                      values of AIx are associated with a higher likelihood for
                      HFpEF in elderly males but not in females.},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:35581324},
      doi          = {10.1038/s41371-022-00703-y},
      url          = {https://inrepo02.dkfz.de/record/179952},
}