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@ARTICLE{Mittmann:180026,
      author       = {B. J. Mittmann and A. Seitel$^*$ and G. Echner$^*$ and W.
                      Johnen$^*$ and R. Gnirs$^*$ and L. Maier-Hein$^*$ and A.
                      Franz$^*$},
      title        = {{R}eattachable fiducial skin marker for automatic
                      multimodality registration.},
      journal      = {International journal of computer assisted radiology and
                      surgery},
      volume       = {17},
      number       = {11},
      issn         = {1861-6410},
      address      = {Heidelberg [u.a.]},
      publisher    = {Springer},
      reportid     = {DKFZ-2022-01043},
      pages        = {2141-2150},
      year         = {2022},
      note         = {#LA:E130# / 2022 Nov;17(11):2141-2150},
      abstract     = {Fusing image information has become increasingly important
                      for optimal diagnosis and treatment of the patient. Despite
                      intensive research towards markerless registration
                      approaches, fiducial marker-based methods remain the default
                      choice for a wide range of applications in clinical
                      practice. However, as especially non-invasive markers cannot
                      be positioned reproducibly in the same pose on the patient,
                      pre-interventional imaging has to be performed immediately
                      before the intervention for fiducial marker-based
                      registrations.We propose a new non-invasive, reattachable
                      fiducial skin marker concept for multi-modal registration
                      approaches including the use of electromagnetic or optical
                      tracking technologies. We furthermore describe a robust,
                      automatic fiducial marker localization algorithm for
                      computed tomography (CT) and magnetic resonance imaging
                      (MRI) images. Localization of the new fiducial marker has
                      been assessed for different marker configurations using both
                      CT and MRI. Furthermore, we applied the marker in an
                      abdominal phantom study. For this, we attached the marker at
                      three poses to the phantom, registered ten segmented targets
                      of the phantom's CT image to live ultrasound images and
                      determined the target registration error (TRE) for each
                      target and each marker pose.Reattachment of the marker was
                      possible with a mean precision of 0.02 mm ± 0.01 mm. Our
                      algorithm successfully localized the marker automatically in
                      all ([Formula: see text]) evaluated CT/MRI images. Depending
                      on the marker pose, the mean ([Formula: see text]) TRE of
                      the abdominal phantom study ranged from 1.51 ± 0.75 mm to
                      4.65 ± 1.22 mm.The non-invasive, reattachable skin marker
                      concept allows reproducible positioning of the marker and
                      automatic localization in different imaging modalities. The
                      low TREs indicate the potential applicability of the marker
                      concept for clinical interventions, such as the puncture of
                      abdominal lesions, where current image-based registration
                      approaches still lack robustness and existing marker-based
                      methods are often impractical.},
      keywords     = {Automatic multimodality registration (Other) / Fiducial
                      marker assessment (Other) / Reattachable fiducial skin
                      marker (Other)},
      cin          = {E130 / E040 / E010},
      ddc          = {610},
      cid          = {I:(DE-He78)E130-20160331 / I:(DE-He78)E040-20160331 /
                      I:(DE-He78)E010-20160331},
      pnm          = {315 - Bildgebung und Radioonkologie (POF4-315)},
      pid          = {G:(DE-HGF)POF4-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:35604488},
      doi          = {10.1007/s11548-022-02639-7},
      url          = {https://inrepo02.dkfz.de/record/180026},
}