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000180029 1001_ $$00000-0001-6370-2243$$aYang, Jae Jeong$$b0
000180029 245__ $$aPrediagnosis Leisure-Time Physical Activity and Lung Cancer Survival: A Pooled Analysis of 11 Cohorts.
000180029 260__ $$aOxford$$bOxford University Press$$c2022
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000180029 520__ $$aLittle is known about the association between physical activity before cancer diagnosis and survival among lung cancer patients. In this pooled analysis of 11 prospective cohorts, we investigated associations of prediagnosis leisure-time physical activity (LTPA) with all-cause and lung cancer-specific mortality among incident lung cancer patients.Using self-reported data on regular engagement in exercise and sports activities collected at study enrollment, we assessed metabolic equivalent hours (MET-h) of prediagnosis LTPA per week. According to the Physical Activity Guidelines for Americans, prediagnosis LTPA was classified into inactivity, less than 8.3 and at least 8.3 MET-h per week (the minimum recommended range). Cox regression was used to estimate hazard ratios (HRs) and 95% confidence interval (CIs) for all-cause and lung cancer-specific mortality after adjustment for major prognostic factors and lifetime smoking history.Of 20 494 incident lung cancer patients, 16 864 died, including 13 596 deaths from lung cancer (overall 5-year relative survival rate = 20.9%, 95% CI = 20.3% to 21.5%). Compared with inactivity, prediagnosis LTPA of more than 8.3 MET-h per week was associated with a lower hazard of all-cause mortality (multivariable-adjusted HR = 0.93, 95% CI = 0.88 to 0.99), but not with lung cancer-specific mortality (multivariable-adjusted HR = 0.99, 95% CI = 0.95 to 1.04), among the overall population. Additive interaction was found by tumor stage (Pinteraction = .008 for all-cause mortality and .003 for lung cancer-specific mortality). When restricted to localized cancer, prediagnosis LTPA of at least 8.3 MET-h per week linked to 20% lower mortality: multivariable-adjusted HRs were 0.80 (95% CI = 0.67 to 0.97) for all-cause mortality and 0.80 (95% CI = 0.65 to 0.99) for lung cancer-specific mortality.Regular participation in LTPA that met or exceeded the minimum Physical Activity Guidelines was associated with reduced hazards of mortality among lung cancer patients, especially those with early stage cancer.
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000180029 7001_ $$00000-0002-1710-9382$$aYu, Danxia$$b1
000180029 7001_ $$aWhite, Emily$$b2
000180029 7001_ $$aLee, Dong Hoon$$b3
000180029 7001_ $$aBlot, William$$b4
000180029 7001_ $$00000-0002-2120-2280$$aRobien, Kim$$b5
000180029 7001_ $$aSinha, Rashmi$$b6
000180029 7001_ $$00000-0002-6281-489X$$aPark, Yikyung$$b7
000180029 7001_ $$aTakata, Yumie$$b8
000180029 7001_ $$aGao, Yu-Tang$$b9
000180029 7001_ $$00000-0002-1932-7463$$aSmith-Byrne, Karl$$b10
000180029 7001_ $$aMonninkhof, Evelyn M$$b11
000180029 7001_ $$0P:(DE-He78)4b2dc91c9d1ac33a1c0e0777d0c1697a$$aKaaks, Rudolf$$b12$$udkfz
000180029 7001_ $$aLanghammer, Arnulf$$b13
000180029 7001_ $$aBorch, Kristin Benjaminsen$$b14
000180029 7001_ $$00000-0003-2774-3464$$aAl-Shaar, Laila$$b15
000180029 7001_ $$aLan, Qing$$b16
000180029 7001_ $$aSørgjerd, Elin Pettersen$$b17
000180029 7001_ $$aZhang, Xuehong$$b18
000180029 7001_ $$aZhu, Clair$$b19
000180029 7001_ $$aChirlaque, María Dolores$$b20
000180029 7001_ $$00000-0001-7157-419X$$aSeveri, Gianluca$$b21
000180029 7001_ $$00000-0001-6429-7921$$aOvervad, Kim$$b22
000180029 7001_ $$00000-0002-8008-5096$$aSacerdote, Carlotta$$b23
000180029 7001_ $$00000-0002-4533-1722$$aAune, Dagfinn$$b24
000180029 7001_ $$00000-0002-3116-5081$$aJohansson, Mattias$$b25
000180029 7001_ $$00000-0003-3462-8608$$aSmith-Warner, Stephanie A$$b26
000180029 7001_ $$aZheng, Wei$$b27
000180029 7001_ $$00000-0002-0711-8314$$aShu, Xiao-Ou$$b28
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