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@ARTICLE{Yang:180029,
      author       = {J. J. Yang and D. Yu and E. White and D. H. Lee and W. Blot
                      and K. Robien and R. Sinha and Y. Park and Y. Takata and
                      Y.-T. Gao and K. Smith-Byrne and E. M. Monninkhof and R.
                      Kaaks$^*$ and A. Langhammer and K. B. Borch and L. Al-Shaar
                      and Q. Lan and E. P. Sørgjerd and X. Zhang and C. Zhu and
                      M. D. Chirlaque and G. Severi and K. Overvad and C.
                      Sacerdote and D. Aune and M. Johansson and S. A.
                      Smith-Warner and W. Zheng and X.-O. Shu},
      title        = {{P}rediagnosis {L}eisure-{T}ime {P}hysical {A}ctivity and
                      {L}ung {C}ancer {S}urvival: {A} {P}ooled {A}nalysis of 11
                      {C}ohorts.},
      journal      = {JNCI cancer spectrum},
      volume       = {6},
      number       = {2},
      issn         = {2515-5091},
      address      = {Oxford},
      publisher    = {Oxford University Press},
      reportid     = {DKFZ-2022-01046},
      pages        = {pkac009},
      year         = {2022},
      abstract     = {Little is known about the association between physical
                      activity before cancer diagnosis and survival among lung
                      cancer patients. In this pooled analysis of 11 prospective
                      cohorts, we investigated associations of prediagnosis
                      leisure-time physical activity (LTPA) with all-cause and
                      lung cancer-specific mortality among incident lung cancer
                      patients.Using self-reported data on regular engagement in
                      exercise and sports activities collected at study
                      enrollment, we assessed metabolic equivalent hours (MET-h)
                      of prediagnosis LTPA per week. According to the Physical
                      Activity Guidelines for Americans, prediagnosis LTPA was
                      classified into inactivity, less than 8.3 and at least 8.3
                      MET-h per week (the minimum recommended range). Cox
                      regression was used to estimate hazard ratios (HRs) and
                      $95\%$ confidence interval (CIs) for all-cause and lung
                      cancer-specific mortality after adjustment for major
                      prognostic factors and lifetime smoking history.Of 20 494
                      incident lung cancer patients, 16 864 died, including 13 596
                      deaths from lung cancer (overall 5-year relative survival
                      rate = $20.9\%,$ $95\%$ CI = $20.3\%$ to $21.5\%).$ Compared
                      with inactivity, prediagnosis LTPA of more than 8.3 MET-h
                      per week was associated with a lower hazard of all-cause
                      mortality (multivariable-adjusted HR = 0.93, $95\%$ CI =
                      0.88 to 0.99), but not with lung cancer-specific mortality
                      (multivariable-adjusted HR = 0.99, $95\%$ CI = 0.95 to
                      1.04), among the overall population. Additive interaction
                      was found by tumor stage (Pinteraction = .008 for all-cause
                      mortality and .003 for lung cancer-specific mortality). When
                      restricted to localized cancer, prediagnosis LTPA of at
                      least 8.3 MET-h per week linked to $20\%$ lower mortality:
                      multivariable-adjusted HRs were 0.80 $(95\%$ CI = 0.67 to
                      0.97) for all-cause mortality and 0.80 $(95\%$ CI = 0.65 to
                      0.99) for lung cancer-specific mortality.Regular
                      participation in LTPA that met or exceeded the minimum
                      Physical Activity Guidelines was associated with reduced
                      hazards of mortality among lung cancer patients, especially
                      those with early stage cancer.},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:35603841},
      doi          = {10.1093/jncics/pkac009},
      url          = {https://inrepo02.dkfz.de/record/180029},
}