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000180064 1001_ $$0P:(DE-HGF)0$$aCardoso, Rafael$$b0$$eFirst author
000180064 245__ $$aProportion and stage distribution of screen-detected and non-screen-detected colorectal cancer in nine European countries: an international, population-based study.
000180064 260__ $$aLondon$$bElsevier$$c2022
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000180064 500__ $$a#EA:C120#LA:C120#LA:C070#  / 2022 Aug;7(8):711-723 /The lancet. Gastroenterology & hepatology
000180064 520__ $$aThe effects of recently implemented colorectal cancer screening programmes in Europe on colorectal cancer mortality will take several years to be fully known. We aimed to analyse the characteristics and parameters of screening programmes, proportions of colorectal cancers detected through screening, and stage distribution in screen-detected and non-screen-detected colorectal cancers to provide a timely assessment of the potential effects of screening programmes in several European countries.We conducted this population-based study in nine European countries for which data on mode of detection were available (Belgium, Denmark, England, France, Italy, Ireland, the Netherlands, Slovenia, and Spain). Data from 16 population-based cancer registries were included. Patients were included if they were diagnosed with colorectal cancer from the year that organised colorectal cancer screening programmes were implemented in each country until the latest year with available data at the time of analysis, and if their age at diagnosis fell within the age groups targeted by the programmes. Data collected included sex, age at diagnosis, date of diagnosis, topography, morphology, clinical and pathological TNM information based on the edition in place at time of diagnosis, and mode of detection (ie, screen detected or non-screen detected). If stage information was not available, patients were not included in stage-specific analyses. The primary outcome was proportion and stage distribution of screen-detected versus non-screen detected colorectal cancers.228 667 colorectal cancer cases were included in the analyses. Proportions of screen-detected cancers varied widely across countries and regions. The highest proportions (40-60%) were found in Slovenia and the Basque Country in Spain, where FIT-based programmes were fully rolled out, and participation rates were higher than 50%. A similar proportion of screen-detected cancers was also found for the Netherlands in 2015, where participation was over 70%, even though the programme had not yet been fully rolled out to all age groups. In most other countries and regions, proportions of screen-detected cancers were below 30%. Compared with non-screen-detected cancers, screen-detected cancers were much more often found in the distal colon (range 34·5-51·1% screen detected vs 26·4-35·7% non-screen detected) and less often in the proximal colon (19·5-29·9% screen detected vs 24·9-32·8% non-screen detected) p≤0·02 for each country, more often at stage I (35·7-52·7% screen detected vs 13·2-24·9% non-screen detected), and less often at stage IV (5·8-12·5% screen detected vs 22·5-31·9% non-screen detected) p<0·0001 for each country.The proportion of colorectal cancer cases detected by screening varied widely between countries. However, in all countries, screen-detected cancers had a more favourable stage distribution than cancers detected otherwise. There is still much need and scope for improving early detection of cancer across all segments of the colorectum, and particularly in the proximal colon and rectum.Deutsche Krebshilfe.
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000180064 7001_ $$0P:(DE-He78)0311ebf3415e41860b4e2c56fbae6919$$aGuo, Feng$$b1$$udkfz
000180064 7001_ $$0P:(DE-HGF)0$$aHeisser, Thomas$$b2
000180064 7001_ $$aDe Schutter, Harlinde$$b3
000180064 7001_ $$aVan Damme, Nancy$$b4
000180064 7001_ $$aNilbert, Mef Christina$$b5
000180064 7001_ $$aTybjerg, Anne Julie$$b6
000180064 7001_ $$aBouvier, Anne-Marie$$b7
000180064 7001_ $$aBouvier, Véronique$$b8
000180064 7001_ $$aLaunoy, Guy$$b9
000180064 7001_ $$aWoronoff, Anne-Sophie$$b10
000180064 7001_ $$aCariou, Mélanie$$b11
000180064 7001_ $$aRobaszkiewicz, Michel$$b12
000180064 7001_ $$aDelafosse, Patricia$$b13
000180064 7001_ $$aPoncet, Florence$$b14
000180064 7001_ $$aWalsh, Paul M$$b15
000180064 7001_ $$aSenore, Carlo$$b16
000180064 7001_ $$aRosso, Stefano$$b17
000180064 7001_ $$aLemmens, Valery E P P$$b18
000180064 7001_ $$aElferink, Marloes A G$$b19
000180064 7001_ $$aTomšič, Sonja$$b20
000180064 7001_ $$aŽagar, Tina$$b21
000180064 7001_ $$aLopez de Munain Marques, Arantza$$b22
000180064 7001_ $$aMarcos-Gragera, Rafael$$b23
000180064 7001_ $$aPuigdemont, Montse$$b24
000180064 7001_ $$aGalceran, Jaume$$b25
000180064 7001_ $$aCarulla, Marià$$b26
000180064 7001_ $$aSánchez-Gil, Antonia$$b27
000180064 7001_ $$aChirlaque, María-Dolores$$b28
000180064 7001_ $$0P:(DE-He78)6c5d058b7552d071a7fa4c5e943fff0f$$aHoffmeister, Michael$$b29$$udkfz
000180064 7001_ $$0P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2$$aBrenner, Hermann$$b30$$eLast author$$udkfz
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