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@ARTICLE{Tian:180090,
author = {Y. Tian$^*$ and A. E. Kim and S. A. Bien and Y. Lin and C.
Qu and T. Harrison and R. Carreras-Torres and V.
Díez-Obrero and N. Dimou and D. A. Drew and A. Hidaka and
J. R. Huyghe and K. M. Jordahl and J. Morrison and N. Murphy
and M. Obón-Santacana and C. M. Ulrich and J. Ose and A. R.
Peoples and E. A. Ruiz-Narvaez and A. Shcherbina and M.
Stern and Y.-R. Su and F. J. B. van Duijnhoven and V.
Arndt$^*$ and J. Baurley and S. I. Berndt and D. T. Bishop
and H. Brenner$^*$ and D. D. Buchanan and A. T. Chan and J.
C. Figueiredo and S. Gallinger and S. B. Gruber and S.
Harlid and M. Hoffmeister$^*$ and M. A. Jenkins and A. D.
Joshi and T. O. Keku and S. C. Larsson and L. Le Marchand
and L. Li and G. G. Giles and R. L. Milne and H. Nan and R.
Nassir and S. Ogino and A. Budiarto and E. A. Platz and J.
D. Potter and R. L. Prentice and G. Rennert and L. C. Sakoda
and R. E. Schoen and M. L. Slattery and S. N. Thibodeau and
B. Van Guelpen and K. Visvanathan and E. White and A. Wolk
and M. O. Woods and A. H. Wu and P. T. Campbell and G. Casey
and D. V. Conti and M. J. Gunter and A. Kundaje and J. P.
Lewinger and V. Moreno and P. A. Newcomb and B. Pardamean
and D. C. Thomas and K. K. Tsilidis and U. Peters and W. J.
Gauderman and L. Hsu and J. Chang-Claude$^*$},
title = {{G}enome-{W}ide {I}nteraction {A}nalysis of {G}enetic
{V}ariants with {M}enopausal {H}ormone {T}herapy for
{C}olorectal {C}ancer {R}isk.},
journal = {Journal of the National Cancer Institute},
volume = {114},
number = {8},
issn = {0027-8874},
address = {Oxford},
publisher = {Oxford Univ. Press},
reportid = {DKFZ-2022-01089},
pages = {1135-1148},
year = {2022},
note = {#EA:C020#LA:C020# / 2022 Aug 8;114(8):1135-1148},
abstract = {The use of menopausal hormone therapy (MHT) may interact
with genetic variants to influence colorectal cancer (CRC)
risk.We conducted a genome-wide gene-environment interaction
between single nucleotide polymorphisms and the use of any
MHT, estrogen-only, and combined estrogen-progestogen
therapy with CRC risk, among 28,486 postmenopausal women
(11,519 cases and 16,967 controls) from 38 studies, using
logistic regression, two-step method, and 2- or
3-degree-of-freedom (d.f.) joint test. A set-based score
test was applied for rare genetic variants.The use of any
MHT, estrogen-only and estrogen-progestogen were associated
with a reduced CRC risk [odds ratio (OR) with $95\%$
confidence interval $(95\%$ CI) of 0.71 (0.64-0.78), 0.65
(0.53-0.79), and 0.73 (0.59-0.90), respectively]. The
two-step method identified a statistically significant
interaction between a GRIN2B variant rs117868593 and MHT
use, whereby MHT-associated CRC risk was significantly
reduced in women with the GG genotype [0.68 (0.64-0.72)] but
not within strata of GC or CC genotypes. A statistically
significant interaction between a DCBLD1 intronic variant at
6q22.1 (rs10782186) and MHT use was identified by the 2-d.f.
joint test. The MHT-associated CRC risk was reduced with
increasing number of rs10782186-C alleles, showing ORs of
0.78 (0.70-0.87) for TT, 0.68 (0.63-0.73) for TC, and 0.66
(0.60-0.74) for CC genotypes. In addition, five genes in
rare variant analysis showed suggestive interactions with
MHT (two-sided P < 1.2x10-4).Genetic variants that modify
the association between MHT and CRC risk were identified,
offering new insights into pathways of CRC carcinogenesis
and potential mechanisms involved.},
cin = {C020 / C071 / C070 / C120 / HD01},
ddc = {610},
cid = {I:(DE-He78)C020-20160331 / I:(DE-He78)C071-20160331 /
I:(DE-He78)C070-20160331 / I:(DE-He78)C120-20160331 /
I:(DE-He78)HD01-20160331},
pnm = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
pid = {G:(DE-HGF)POF4-313},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:35512400},
doi = {10.1093/jnci/djac094},
url = {https://inrepo02.dkfz.de/record/180090},
}