000180104 001__ 180104
000180104 005__ 20240229145605.0
000180104 0247_ $$2doi$$a10.1186/s12877-022-03151-y
000180104 0247_ $$2pmid$$apmid:35619073
000180104 037__ $$aDKFZ-2022-01097
000180104 041__ $$aEnglish
000180104 082__ $$a610
000180104 1001_ $$0P:(DE-He78)6e300fa6ddaf211b74fd4fd4984745a6$$aXie, Kun$$b0$$eFirst author
000180104 245__ $$aType 2 diabetes mellitus and cognitive decline in older adults in Germany - results from a population-based cohort.
000180104 260__ $$aLondon$$bBioMed Central$$c2022
000180104 3367_ $$2DRIVER$$aarticle
000180104 3367_ $$2DataCite$$aOutput Types/Journal article
000180104 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1653990125_21816
000180104 3367_ $$2BibTeX$$aARTICLE
000180104 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000180104 3367_ $$00$$2EndNote$$aJournal Article
000180104 500__ $$a#EA:C070#LA:C070#
000180104 520__ $$aA large body of evidence supports a link between type 2 diabetes mellitus (T2DM) and cognitive function, including dementia. However, longitudinal studies on the association between T2DM and decline of cognitive function are scarce and reported mixed results, and we hence set out to investigate the cross-sectional and longitudinal association between T2DM and global as well as domain-specific cognitive performance.We used multivariable regression models to assess associations of T2DM with cognitive performance and cognitive decline in a subsample of a population-based prospective cohort study (ESTHER). This subsample (n = 732) was aged 70 years and older and had participated in telephone-based cognitive function assessment (COGTEL) measuring global and domain-specific cognitive performance during the 5- and 8-year follow-up.Total COGTEL scores of patients with prevalent T2DM were 27.4 ± 8.3 and 29.4 ± 8.7 at the 5- and 8-year measurements, respectively, and were roughly two points lower than those of T2DM-free participants after adjustment for age and sex. In cross-sectional models, after adjustment for several potential confounders, performance in verbal short-term and long-term memory tasks was statistically significantly lower in participants with T2DM, but the association was attenuated after further adjustment for vascular risk factors. The difference in total COGTEL scores reflecting global cognitive function by T2DM status after full adjustment for confounders and vascular risk factors was equivalent to a decrement in global cognitive function associated with a four-year age difference. In longitudinal models, a statistically significantly stronger cognitive decline in patients with T2DM was observed for working memory.In this sample of older individuals, T2DM was associated with worse performance and stronger decline in a cognitive function test. Memory-related domains were found to be particularly sensitive to T2DM. Further large-scale prospective studies are needed to clarify potential T2DM-related predictors of cognitive decline and possible consequences on the abilities to perform patient self-management tasks in diabetes care.
000180104 536__ $$0G:(DE-HGF)POF4-313$$a313 - Krebsrisikofaktoren und Prävention (POF4-313)$$cPOF4-313$$fPOF IV$$x0
000180104 588__ $$aDataset connected to CrossRef, PubMed, , Journals: inrepo02.dkfz.de
000180104 650_7 $$2Other$$aCognitive decline
000180104 650_7 $$2Other$$aCognitive function
000180104 650_7 $$2Other$$aType 2 diabetes mellitus
000180104 650_7 $$2Other$$aVascular risk factors
000180104 7001_ $$0P:(DE-He78)c67a12496b8aac150c0eef888d808d46$$aSchöttker, Ben$$b1$$udkfz
000180104 7001_ $$0P:(DE-He78)d9d72431035d8535d1b65ce9a01c2f60$$aPerna, Laura$$b2$$udkfz
000180104 7001_ $$aKliegel, Matthias$$b3
000180104 7001_ $$0P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2$$aBrenner, Hermann$$b4$$udkfz
000180104 7001_ $$0P:(DE-He78)1b59582b6c05ac4e57aa8b90dd9667f9$$aMons, Ute$$b5$$eLast author$$udkfz
000180104 773__ $$0PERI:(DE-600)2059865-8$$a10.1186/s12877-022-03151-y$$gVol. 22, no. 1, p. 455$$n1$$p455$$tBMC geriatrics$$v22$$x1471-2318$$y2022
000180104 909CO $$ooai:inrepo02.dkfz.de:180104$$pVDB
000180104 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)6e300fa6ddaf211b74fd4fd4984745a6$$aDeutsches Krebsforschungszentrum$$b0$$kDKFZ
000180104 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)c67a12496b8aac150c0eef888d808d46$$aDeutsches Krebsforschungszentrum$$b1$$kDKFZ
000180104 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)d9d72431035d8535d1b65ce9a01c2f60$$aDeutsches Krebsforschungszentrum$$b2$$kDKFZ
000180104 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2$$aDeutsches Krebsforschungszentrum$$b4$$kDKFZ
000180104 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)1b59582b6c05ac4e57aa8b90dd9667f9$$aDeutsches Krebsforschungszentrum$$b5$$kDKFZ
000180104 9131_ $$0G:(DE-HGF)POF4-313$$1G:(DE-HGF)POF4-310$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lKrebsforschung$$vKrebsrisikofaktoren und Prävention$$x0
000180104 9141_ $$y2022
000180104 915__ $$0LIC:(DE-HGF)CCBYNV$$2V:(DE-HGF)$$aCreative Commons Attribution CC BY (No Version)$$bDOAJ$$d2021-05-04
000180104 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2021-05-04
000180104 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2021-05-04
000180104 915__ $$0StatID:(DE-HGF)0561$$2StatID$$aArticle Processing Charges$$d2021-05-04
000180104 915__ $$0StatID:(DE-HGF)0700$$2StatID$$aFees$$d2021-05-04
000180104 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bBMC GERIATR : 2021$$d2022-11-15
000180104 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2022-11-15
000180104 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2022-11-15
000180104 915__ $$0StatID:(DE-HGF)0501$$2StatID$$aDBCoverage$$bDOAJ Seal$$d2021-02-14T16:18:44Z
000180104 915__ $$0StatID:(DE-HGF)0500$$2StatID$$aDBCoverage$$bDOAJ$$d2021-02-14T16:18:44Z
000180104 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bDOAJ : Open peer review$$d2021-02-14T16:18:44Z
000180104 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2022-11-15
000180104 915__ $$0StatID:(DE-HGF)1180$$2StatID$$aDBCoverage$$bCurrent Contents - Social and Behavioral Sciences$$d2022-11-15
000180104 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2022-11-15
000180104 915__ $$0StatID:(DE-HGF)0130$$2StatID$$aDBCoverage$$bSocial Sciences Citation Index$$d2022-11-15
000180104 915__ $$0StatID:(DE-HGF)9900$$2StatID$$aIF < 5$$d2022-11-15
000180104 9202_ $$0I:(DE-He78)C070-20160331$$kC070$$lC070 Klinische Epidemiologie und Alternf.$$x0
000180104 9201_ $$0I:(DE-He78)C070-20160331$$kC070$$lC070 Klinische Epidemiologie und Alternf.$$x0
000180104 9200_ $$0I:(DE-He78)C070-20160331$$kC070$$lC070 Klinische Epidemiologie und Alternf.$$x0
000180104 980__ $$ajournal
000180104 980__ $$aVDB
000180104 980__ $$aI:(DE-He78)C070-20160331
000180104 980__ $$aUNRESTRICTED