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@ARTICLE{Koskinen:180113,
author = {A. Koskinen and O. Hemminki and A. Försti$^*$ and K.
Hemminki$^*$},
title = {{I}ncidence and survival in laryngeal and lung cancers in
{F}inland and {S}weden through a half century.},
journal = {PLOS ONE},
volume = {17},
number = {5},
issn = {1932-6203},
address = {San Francisco, California, US},
publisher = {PLOS},
reportid = {DKFZ-2022-01106},
pages = {e0268922 -},
year = {2022},
abstract = {Global survival studies have shown favorable development in
most cancers but few studies have considered laryngeal
cancer, particularly over extended periods or in populations
for which medical care is essentially free of charge. We
analyzed laryngeal and lung cancer incidence and survival in
Finland (FI) and Sweden (SE) over a 50-year period
(1970-2019) using data and statistical tools from the
Nordcan database. Laryngeal cancer reached an incidence
maximum in FI men in 1965, which in SE men occurred over 10
years later and peaking at $42\%$ of the FI maximum. The FI
incidence halved in 20 years while halving of the SE rate
took almost twice as long. At maximum the male rate exceeded
the female rate 20 times in FI and 10 times in SE. Incidence
rates for lung cancer were approximately 10 times higher
than those for laryngeal cancer, and they peaked 5 to 10
years after laryngeal cancer in both countries. The female
lung cancer rates increased through the follow-up time but
laryngeal cancer rates were relatively stable. Relative
1-year survival data for laryngeal cancer remained at around
$85\%$ through 50 years, and 5-year survival lagged
constantly around $65\%.$ For lung cancer 1-year survival
improved and reached about $50\%$ by 2019. Even 5-year
survival improved reaching 20 to $30\%,$ except for FI men.
Incidence rates for laryngeal and lung cancers have
drastically decreased in FI and SE men parallel to reduced
smoking prevalence. In females, rates have clearly increased
in lung but not in FI laryngeal cancer. This finding
warrants further investigations into possible contributing
factors, other than smoking. Survival in laryngeal cancer
has not improved compared to the positive development in
lung cancer. Historical smoking prevalence was unrelated of
survival trends. As long-term survival in these cancers
remains discouraging, the most efficient way to fight them
is to target the main cause and promote non-smoking.},
cin = {B062 / HD01},
ddc = {610},
cid = {I:(DE-He78)B062-20160331 / I:(DE-He78)HD01-20160331},
pnm = {312 - Funktionelle und strukturelle Genomforschung
(POF4-312)},
pid = {G:(DE-HGF)POF4-312},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:35622857},
doi = {10.1371/journal.pone.0268922},
url = {https://inrepo02.dkfz.de/record/180113},
}