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| Home > Publications database > Strongly increased risk of gastric and duodenal ulcers among new users of low-dose aspirin: Results from two large cohorts with new-user design. > print |
| Home > Publications database > Strongly increased risk of gastric and duodenal ulcers among new users of low-dose aspirin: Results from two large cohorts with new-user design. > print |
| 001 | 180118 | ||
| 005 | 20241220120850.0 | ||
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| 100 | 1 | _ | |a Nguyen, Mai Thi Ngoc |0 P:(DE-He78)abb10265fc5b7b424eee557e979d490f |b 0 |e First author |u dkfz |
| 245 | _ | _ | |a Strongly increased risk of gastric and duodenal ulcers among new users of low-dose aspirin: Results from two large cohorts with new-user design. |
| 260 | _ | _ | |a Oxford |c 2022 |b Wiley-Blackwell |
| 264 | _ | 1 | |3 online |2 Crossref |b Wiley |c 2022-05-27 |
| 264 | _ | 1 | |3 print |2 Crossref |b Wiley |c 2022-07-01 |
| 264 | _ | 1 | |3 print |2 Crossref |b Wiley |c 2022-07-01 |
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| 500 | _ | _ | |a #EA:C070#LA:C070# / 2022 Jul;56(2):251-262 |
| 520 | _ | _ | |a Low-dose aspirin is a risk factor for peptic ulcer disease but previous, population-based cohort studies may have underestimated the low-dose aspirin risk because they did not use a new-user design. Gastrointestinal bleeding occurs more frequently early after initiation of low-dose aspirin therapy than in later years.To assess the associations of low-dose aspirin with gastric and duodenal ulcer incidence in prevalent- and new-user design.Multivariate Cox regression models in the German ESTHER study (N = 7737) and the UK Biobank (N = 213,598) with more than 10 years of follow-up.In the prevalent-user design, there was no significant association between low-dose aspirin and gastric ulcer observed in both cohorts. Furthermore, low-dose aspirin was weakly, statistically significantly associated with prevalent duodenal ulcer in the UK Biobank (hazard ratio [95% confidence interval]: 1.27 [1.07-1.51]) but not in the ESTHER study (1.33 [0.54-3.29]). When restricting the exposure to only new users, the hazard ratios for incident gastric and duodenal ulcer disease were 1.82 [1.58-2.11] and 1.66 [1.36-2.04] in the UK Biobank, respectively, and 2.83 [1.40-5.71] and 3.89 [1.46-10.42] in the ESTHER study, respectively.This study shows that low-dose aspirin is an independent risk factor for both gastric and duodenal ulcers. The associations were not significant or weak in the prevalent-user design and strong and statistically significant in the new-user design in both cohorts. Thus, it is important to weigh risks against benefits when low-dose aspirin treatment shall be initiated and to monitor adverse gastrointestinal symptoms after the start of low-dose aspirin therapy. |
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| 542 | _ | _ | |i 2022-05-27 |2 Crossref |u http://creativecommons.org/licenses/by/4.0/ |
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