%0 Journal Article
%A Nguyen, Mai Thi Ngoc
%A Chen, Li-Ju
%A Trares, Kira
%A Stocker, Hannah
%A Holleczek, Bernd
%A Beyreuther, Konrad
%A Brenner, Hermann
%A Schöttker, Ben
%T Long-term low-dose acetylsalicylic use shows protective potential for the development of both vascular dementia and Alzheimer's disease in patients with coronary heart disease but not in other individuals from the general population: results from two large cohort studies.
%J Alzheimer's research & therapy
%V 14
%N 1
%@ 1758-9193
%C London
%I BioMed Central
%M DKFZ-2022-01173
%P 75
%D 2022
%Z #EA:C070#LA:C070#
%X No population-based cohort study investigated a potential inverse association between long-term low-dose acetylsalicylic acid (ASA) use and all-cause dementia and its two most common sub-types Alzheimer's disease (AD) and vascular dementia (VD) so far.Cox regression models with inverse probability of treatment weighting to model the underlying cardiovascular risk were used to assess the associations of low-dose ASA use with all-cause dementia, AD, and VD incidence in community-dwelling older adults from the German ESTHER study (N = 5258) and the UK Biobank (N = 305,394). Inclusion criteria were age of 55 years or older and completed drug assessment. Meta-analyses of the individual participant data from the two prospective cohort studies were performed.Four hundred seventy-six cases of all-cause dementia, 157 cases of AD, and 183 cases of VD were diagnosed over a median of 14.3 years of follow-up in ESTHER. In the UK Biobank, 5584 participants were diagnosed with all-cause dementia, 2029 with AD, and 1437 with VD over a median of 11.6 years. The meta-analysis of both cohorts revealed a weak reduction in hazards for all-cause dementia (hazard ratio (HR) [95
%K Aged
%K Alzheimer Disease: diagnosis
%K Cohort Studies
%K Coronary Disease: complications
%K Dementia, Vascular: complications
%K Humans
%K Middle Aged
%K Prospective Studies
%K Risk Factors
%K Acetylsalicylic acid (Other)
%K Alzheimer’s disease (Other)
%K Aspirin (Other)
%K Cohort study (Other)
%K Coronary heart disease (Other)
%K Dementia (Other)
%K Meta-analysis (Other)
%K Prevention (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:35624487
%R 10.1186/s13195-022-01017-4
%U https://inrepo02.dkfz.de/record/180222