TY  - JOUR
AU  - Nguyen, Mai Thi Ngoc
AU  - Chen, Li-Ju
AU  - Trares, Kira
AU  - Stocker, Hannah
AU  - Holleczek, Bernd
AU  - Beyreuther, Konrad
AU  - Brenner, Hermann
AU  - Schöttker, Ben
TI  - Long-term low-dose acetylsalicylic use shows protective potential for the development of both vascular dementia and Alzheimer's disease in patients with coronary heart disease but not in other individuals from the general population: results from two large cohort studies.
JO  - Alzheimer's research & therapy
VL  - 14
IS  - 1
SN  - 1758-9193
CY  - London
PB  - BioMed Central
M1  - DKFZ-2022-01173
SP  - 75
PY  - 2022
N1  - #EA:C070#LA:C070#
AB  - No population-based cohort study investigated a potential inverse association between long-term low-dose acetylsalicylic acid (ASA) use and all-cause dementia and its two most common sub-types Alzheimer's disease (AD) and vascular dementia (VD) so far.Cox regression models with inverse probability of treatment weighting to model the underlying cardiovascular risk were used to assess the associations of low-dose ASA use with all-cause dementia, AD, and VD incidence in community-dwelling older adults from the German ESTHER study (N = 5258) and the UK Biobank (N = 305,394). Inclusion criteria were age of 55 years or older and completed drug assessment. Meta-analyses of the individual participant data from the two prospective cohort studies were performed.Four hundred seventy-six cases of all-cause dementia, 157 cases of AD, and 183 cases of VD were diagnosed over a median of 14.3 years of follow-up in ESTHER. In the UK Biobank, 5584 participants were diagnosed with all-cause dementia, 2029 with AD, and 1437 with VD over a median of 11.6 years. The meta-analysis of both cohorts revealed a weak reduction in hazards for all-cause dementia (hazard ratio (HR) [95
KW  - Aged
KW  - Alzheimer Disease: diagnosis
KW  - Cohort Studies
KW  - Coronary Disease: complications
KW  - Dementia, Vascular: complications
KW  - Humans
KW  - Middle Aged
KW  - Prospective Studies
KW  - Risk Factors
KW  - Acetylsalicylic acid (Other)
KW  - Alzheimer’s disease (Other)
KW  - Aspirin (Other)
KW  - Cohort study (Other)
KW  - Coronary heart disease (Other)
KW  - Dementia (Other)
KW  - Meta-analysis (Other)
KW  - Prevention (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:35624487
DO  - DOI:10.1186/s13195-022-01017-4
UR  - https://inrepo02.dkfz.de/record/180222
ER  -