TY  - JOUR
AU  - Niedermaier, Tobias
AU  - Guo, Feng
AU  - Weigl, Korbinian
AU  - Hoffmeister, Michael
AU  - Brenner, Hermann
TI  - Combined performance of fecal immunochemical tests and a genetic risk score for advanced neoplasia detection.
JO  - Cancer Prevention Research
VL  - 15
IS  - 8
SN  - 1940-6207
CY  - Philadelphia, Pa.
PB  - AACR
M1  - DKFZ-2022-01215
SP  - 543-552
PY  - 2022
N1  - #EA:C070#LA:C070#C120# / 2022 Aug 1;15(8):543-552
AB  - Fecal immunochemical tests (FITs) are increasingly used as noninvasive screening tests in colorectal cancer (CRC) screening programs. Polygenic risk scores (PRS) are increasingly propagated for risk stratification in CRC screening. We aimed to assess the potential of combining FIT results and PRS to enhance diagnostic accuracy of detecting advanced neoplasia (AN) compared to using FIT results alone. Of 10,362 participants of screening colonoscopy in Southern Germany who conducted either one of two quantitative FITs, genotyping was done in all participants with advanced neoplasia (CRC or advanced adenoma) and a random subset of controls. Among 5,306 individuals, a PRS was calculated based on the number of risk alleles in 140 single nucleotide polymorphisms. Partial areas under the receiver operating characteristics (ROC) curves (pAUCs) were computed for FIT and PRS alone and combined, focusing on a specificity range of 100
LB  - PUB:(DE-HGF)16
C6  - pmid:35679356
DO  - DOI:10.1158/1940-6207.CAPR-21-0552
UR  - https://inrepo02.dkfz.de/record/180269
ER  -