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000180309 1001_ $$0P:(DE-He78)dc4247d1e899d0fd333732064f422a0f$$aLiew, Hans$$b0$$eFirst author$$udkfz
000180309 245__ $$aImpact of DNA Repair Kinetics and Dose Rate on RBE Predictions in the UNIVERSE.
000180309 260__ $$aBasel$$bMolecular Diversity Preservation International$$c2022
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000180309 520__ $$aAccurate knowledge of the relative biological effectiveness (RBE) and its dependencies is crucial to support modern ion beam therapy and its further development. However, the influence of different dose rates of the reference radiation and ion beam are rarely considered. The ion beam RBE-model within our 'UNIfied and VERSatile bio response Engine' (UNIVERSE) is extended by including DNA damage repair kinetics to investigate the impact of dose-rate effects on the predicted RBE. It was found that dose-rate effects increase with dose and biological effects saturate at high dose-rates, which is consistent with data- and model-based studies in the literature. In a comparison with RBE measurements from a high dose in-vivo study, the predictions of the presented modification were found to be improved in comparison to the previous version of UNIVERSE and existing clinical approaches that disregard dose-rate effects. Consequently, DNA repair kinetics and the different dose rates applied by the reference and ion beams might need to be considered in biophysical models to accurately predict the RBE. Additionally, this study marks an important step in the further development of UNIVERSE, extending its capabilities in giving theoretical guidance to support progress in ion beam therapy.
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000180309 650_7 $$2Other$$aDNA repair
000180309 650_7 $$2Other$$aRBE
000180309 650_7 $$2Other$$aUNIVERSE
000180309 650_7 $$2Other$$adose rate
000180309 650_7 $$2Other$$aion beam therapy
000180309 650_7 $$2Other$$aionizing radiation
000180309 650_7 $$2Other$$amodeling
000180309 650_7 $$2Other$$arat spinal cord
000180309 7001_ $$0P:(DE-HGF)0$$aMein, Stewart$$b1
000180309 7001_ $$aTessonnier, Thomas$$b2
000180309 7001_ $$0P:(DE-He78)b43076fb0a30230e4323887c0c980046$$aKarger, Christian$$b3$$udkfz
000180309 7001_ $$0P:(DE-He78)360c5bc2b71a849e35aca747c041dda7$$aAbdollahi, Amir$$b4$$udkfz
000180309 7001_ $$0P:(DE-He78)8714da4e45acfa36ce87c291443a9218$$aDebus, Jürgen$$b5$$udkfz
000180309 7001_ $$0P:(DE-He78)e24b607ded082a3089a1f6bf326a7a8e$$aDokic, Ivana$$b6$$udkfz
000180309 7001_ $$0P:(DE-He78)8d6c2aceda79e88defe1e8c0fcc39d59$$aMairani, Andrea$$b7$$eLast author$$udkfz
000180309 773__ $$0PERI:(DE-600)2019364-6$$a10.3390/ijms23116268$$gVol. 23, no. 11, p. 6268 -$$n11$$p6268$$tInternational journal of molecular sciences$$v23$$x1422-0067$$y2022
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