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000180332 1001_ $$0P:(DE-He78)6cc3cc35505b446fde081e7cd89a4b87$$aMöllers, Tobias$$b0$$eFirst author$$udkfz
000180332 245__ $$aSubjective short-term memory difficulties at ages 50-75 predict dementia risk in a community-based cohort followed over 17 years.
000180332 260__ $$aOxford$$bOxford Univ. Press$$c2022
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000180332 520__ $$aSubjective cognitive decline (SCD) is an established precursor of dementia. However, the relationship between SCD and dementia has been mostly studied among people aged 65+. We aimed to assess the association between subjective memory difficulties at ages 50-75 with all-cause dementia and dementia-subtypes in a community-based cohort with long-term follow-up.6,190 individuals (51% female) aged 50-75 years (median age, 62) attending a general health examination (by a total of 684 general practitioners) in Saarland, Germany, in 2000-2002 were recruited for a community-based cohort study. Subjective difficulties regarding short-term and long-term memory were assessed at baseline with two simple yes/no questions. Associations with dementia (-subtypes) diagnoses during 17 years of follow-up were estimated by Cox proportional hazards models.492 participants were diagnosed with dementia during 17 years of follow-up. Participants with short-term memory difficulties were at higher risk to receive incident all-cause dementia and vascular dementia diagnoses both within 0-9 years (age and sex adjusted hazard ratios (aHR), 1.80 and 2.00, respectively) and within 0-17 years (aHR 1.55 and 1.78, respectively) from recruitment (P < 0.05 in all cases). For clinical Alzheimer's disease, a significant association was only seen within the initial 6 years. There were no associations of long-term memory difficulties with any type of dementia.Subjective difficulties in short-term memory predict both intermediate and long-term risk of vascular and all-cause dementia even among late middle-age adults. These results underline the importance of cardiovascular disease prevention efforts well before old age for maintaining cognitive health.
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000180332 650_7 $$2Other$$acohort study
000180332 650_7 $$2Other$$adementia
000180332 650_7 $$2Other$$aolder people
000180332 650_7 $$2Other$$arisk prediction
000180332 650_7 $$2Other$$asubjective memory
000180332 7001_ $$0P:(DE-He78)104fae0755c89365b7ae32238b3f1f52$$aStocker, Hannah$$b1$$eFirst author$$udkfz
000180332 7001_ $$0P:(DE-He78)d9d72431035d8535d1b65ce9a01c2f60$$aPerna, Laura$$b2$$udkfz
000180332 7001_ $$aRujescu, Dan$$b3
000180332 7001_ $$aHolleczek, Bernd$$b4
000180332 7001_ $$0P:(DE-He78)c67a12496b8aac150c0eef888d808d46$$aSchöttker, Ben$$b5$$udkfz
000180332 7001_ $$0P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2$$aBrenner, Hermann$$b6$$eLast author$$udkfz
000180332 773__ $$0PERI:(DE-600)2065766-3$$a10.1093/ageing/afac113$$gVol. 51, no. 6, p. afac113$$n6$$pafac113$$tAge & ageing$$v51$$x0002-0729$$y2022
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