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@ARTICLE{Mllers:180332,
      author       = {T. Möllers$^*$ and H. Stocker$^*$ and L. Perna$^*$ and D.
                      Rujescu and B. Holleczek and B. Schöttker$^*$ and H.
                      Brenner$^*$},
      title        = {{S}ubjective short-term memory difficulties at ages 50-75
                      predict dementia risk in a community-based cohort followed
                      over 17 years.},
      journal      = {Age $\&$ ageing},
      volume       = {51},
      number       = {6},
      issn         = {0002-0729},
      address      = {Oxford},
      publisher    = {Oxford Univ. Press},
      reportid     = {DKFZ-2022-01259},
      pages        = {afac113},
      year         = {2022},
      note         = {#EA:C070#LA:C070#},
      abstract     = {Subjective cognitive decline (SCD) is an established
                      precursor of dementia. However, the relationship between SCD
                      and dementia has been mostly studied among people aged 65+.
                      We aimed to assess the association between subjective memory
                      difficulties at ages 50-75 with all-cause dementia and
                      dementia-subtypes in a community-based cohort with long-term
                      follow-up.6,190 individuals $(51\%$ female) aged 50-75 years
                      (median age, 62) attending a general health examination (by
                      a total of 684 general practitioners) in Saarland, Germany,
                      in 2000-2002 were recruited for a community-based cohort
                      study. Subjective difficulties regarding short-term and
                      long-term memory were assessed at baseline with two simple
                      yes/no questions. Associations with dementia (-subtypes)
                      diagnoses during 17 years of follow-up were estimated by Cox
                      proportional hazards models.492 participants were diagnosed
                      with dementia during 17 years of follow-up. Participants
                      with short-term memory difficulties were at higher risk to
                      receive incident all-cause dementia and vascular dementia
                      diagnoses both within 0-9 years (age and sex adjusted hazard
                      ratios (aHR), 1.80 and 2.00, respectively) and within 0-17
                      years (aHR 1.55 and 1.78, respectively) from recruitment (P
                      < 0.05 in all cases). For clinical Alzheimer's disease, a
                      significant association was only seen within the initial 6
                      years. There were no associations of long-term memory
                      difficulties with any type of dementia.Subjective
                      difficulties in short-term memory predict both intermediate
                      and long-term risk of vascular and all-cause dementia even
                      among late middle-age adults. These results underline the
                      importance of cardiovascular disease prevention efforts well
                      before old age for maintaining cognitive health.},
      keywords     = {cohort study (Other) / dementia (Other) / older people
                      (Other) / risk prediction (Other) / subjective memory
                      (Other)},
      cin          = {C070},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:35697354},
      doi          = {10.1093/ageing/afac113},
      url          = {https://inrepo02.dkfz.de/record/180332},
}